Innovcare`s Garlip

Innovcare`s Garlip Uses, Dosage, Side Effects, Food Interaction and all others data.

Alpha-linolenic acid (ALA) is a polyunsaturated omega-3 fatty acid. It is a component of many common vegetable oils and is important to human nutrition.

Alpha Linolenic Acid (ALA) is an 18-carbon polyunsaturated fatty acid with three double bonds. It is also called an omega-3 fatty acid, and is essential for all mammals. Alpha-linolenic acid (or omega 3 fatty acid) intake can decrease the risk of cardiovascular diseases by 1) preventing arrhythmias that can lead to sudden cardiac death, 2) decreasing the risk of thrombosis (blood clot formation) that can lead to heart attack or stroke, 3) decreasing serum triglyceride levels, 4) slowing the growth of atherosclerotic plaque, 5) improving vascular endothelial function, 6) lowering blood pressure slightly, and 7) decreasing inflammation. ALA deficiencies can lead to visual problems and sensory neuropathy. Scaly and hemorrhagic skin or scalp inflammations may also develop.

The medicinal parts are the whole fresh bulb, the dried bulb and the oil of Garlic. Garlic contains alliin and its transformation products and sulfur containing essential oil. Garlic oil is not present in fresh or dried garlic bulbs, instead the oil is produced by converting water-soluble thiosulfinates to oil-soluble sulfides via steam distillation. Central to Southern Asia is considered the region of origin. Garlic has been harvested in September and October when the leaves and bulbs are dry. In the United States and Western Europe, garlic is one of the most popular substances used to reduce various risks associated with cardiovascular disease. Garlic preparations have been one of the top-selling herbal supplements in the U.S. market for many years.

Garlic reduces total cholesterol (TC), serum triglycerides (TG) and elevates high density lipoproteins (HDL). It prevents platelet aggregation and thrombus formation, stimulates fibrinolysis, prolongs clotting time, reduces low density lipoprotein (LDL) oxidation. It also reduces systolic and diastolic blood pressure and attenuates age and blood pressure related increases in aortic stiffness and reduces blood glucose levels.

Steroid saponins interfere with the absorption of total and LDL cholesterol from the intestinal lumen, thereby reducing plasma cholesterol level without adversely affecting HDL levels.Increases catabolism of fatty acid-containing lipids, especially triglycerides.Enhances palmitate-induced inhibition of cholesterol biosynthesis.Inhibits cholesterol biosynthesis at the level of b-hydroxy-b-methylglutaryl-CoA (HMG-CoA) reductase.The gamma-glutamylcysteines are the compounds in garlic that may lower blood pressure, as indicated by their ability to inhibit angiotensin-converting enzyme in-vitro. Garlic modulates the production and function of both endothelium derived relaxing and constricting factors and this may contribute to its protective effect against hypoxic pulmonary vasoconstriction.Garlic elicits nitric-oxide-dependent relaxation in pulmonary arteries. It increases nitric oxide through activation of nitric oxide synthase activity.Fructans can inhibit adenosine deaminase in isolated cells, thus increasing adenosine and its associated blood vessel dilatory activity

An unsaturated fatty acid that is the most widely distributed and abundant fatty acid in nature. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. (Stedman, 26th ed)

Innovcare`s Garlip
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Innovcare`s Garlip
Generic	Alpha-linolenic Acid + Garlic Oil + Linoleic Acid + Oleic Acid
Weight	ala
Type	Capsule
Therapeutic Class
Manufacturer	Innovcare Life Sciences Pvt Ltd
Available Country	India
Last Updated:	September 19, 2023 at 7:00 am

Uses

Linolenic acid is a polyunsaturated omega-3 fatty acid found in many supplements.

For nutritional supplementation and for treating dietary shortage or imbalance.

Garlic Oil is used for Hyperlipidemia, Atherosclerosis, Mild Hypertension

Oleic Acid is a naturally occurring fatty acid with antibacterial properties added to a variety of drug products.

Innovcare`s Garlip is also used to associated treatment for these conditions: Nutritional supplementationAcne, Dermatitis, Dry Skin, Parenteral Nutrition

How Innovcare`s Garlip works

Alpha Linolenic Acid or ALA is considered an essential fatty acid because it is required for human health, but cannot be synthesized by humans. It is in fact a plant-derived fatty acid. Humans can synthesize other omega-3 fatty acids from ALA, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). EPA is a precursor of the series-3 prostaglandins, the series-5 leukotrienes and the series-3 thromboxanes. These eicosanoids have anti-inflammatory and anti-atherogenic properties. ALA metabolites may also inhibit the production of the pro-inflammatory eicosanoids, prostaglandin E2 (PGE2) and leukotriene B4 (LTB4), as well as the pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta). Omega-3 fatty acids like ALA and its byproducts can modulate the expression of a number of genes, including those involved with fatty acid metabolism and inflammation. They regulate gene expression through their effects on the activity of transcription factors including NF-kappa B and members of the peroxisome proliferator-activated receptor (PPAR) family. Incorporation of ALA and its metabolites in cell membranes can affect membrane fluidity and may play a role in anti-inflammatory activity, inhibition of platelet aggregation and possibly in anti-proliferative actions of ALA. ALA is first metabolized by delta6 desaturease into steridonic acid.

Dosage

Innovcare`s Garlip dosage

1 to 2 capsules daily for 8 to 18 weeks or as advised by the physician

Side Effects

Gastro-intestinal symptoms, changes to the flora of the intestine and allergic reactions are rare

Toxicity

In rat, oral LD50 74 g/kg and intravenous LD50 is 2.4 mg/kg . Dermal LD50 in guinea pig was >3000 mg/kg .

Interaction

Concurrent use of garlic and antiplatelet agents and anticoagulants might increase the potential for prolonged bleeding. Blood clotting times have been reported to double in patients taking warfarin and garlic suppliments

Volume of Distribution

Radio-labelled oleic acid was detected in the heart, liver, lung, spleen, kidney, muscle, intestine, adrenal, blood, and lymph, and adipose, mucosal, and dental tissues . Oleic acid is primarily transported via the lymphatic system .

Elimination Route

Fatty acid uptake by different tissues may be mediated via passive diffusion to facilitated diffusion or a combination of both . Fatty acids taken up by tissues are then stored in the form of triglycerides or oxidized . Oleic acid was shown to penetrate rat skin . Following oral administration of Brucea javanica oil emulsion in rats, the time of oleic acid to reach peak plasma concentration was approximately 15.6 hours .