Torel (25.40 mg+14.30 mg+4.20 mg+0.05 mg)/gm Muscle Rub

Torel (25.40 mg+14.30 mg+4.20 mg+0.05 mg)/gm Muscle Rub Uses, Dosage, Side Effects, Food Interaction and all others data.

Capsicum species are known to be very strong local stimulants in the circulatory system. Its reduction of thromboxane B2 formation and erythrocyte hemolysis suggests a membrane stabilizing property that interferes with the activation of phospholipase A2.

Capsicum activates nociceptive fbres, which induces the release of excitatory neurotransmitters, bind to specific vanilloid (capsaicin) receptors and its effects are reversible.

Capsicum induces selective analgesic effect by depleting substance P, a neuropeptide of 11 amino acids that mediates the transmission and modulation of pain impulses from the peripheral nerves to the spinal column. Capsicum initially stimulates substance P release from peripheral sensory C type nerve fibers, then prevents its re-uptake and also blocks its transport within the neuron, which causes its eventual depletion resulting in analgesia.

The mode of action of Methyl salicylic acid is similar to that of Aspirin that shows anesthetic properties by blocking the voltage-operated sodium channels in pain-receptor neurons.

The menthol molecule binds and stimulates the TRPM-8 receptor protein that produces a sensation of cold (pain in extreme cases) when stimulated.

FDA has approved camphor for topical use as a pain reliever and anesthetic. It acts as counter irritant and numbs the nerve endings that inhibit the transmission of pain sensation.

Torel (25.40 mg+14.30 mg+4.20 mg+0.05 mg)/gm Muscle Rub
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Torel (25.40 mg+14.30 mg+4.20 mg+0.05 mg)/gm Muscle Rub
Generic	Menthol + Camphor + Methyl Salicylate + Oleoresin Capsicum
Weight	(25.40 mg+14.30 mg+4.20 mg+0.05 mg)/gm
Type	Muscle Rub
Therapeutic Class	Topical Analgesics, Topical anti-inflammatory preparations
Manufacturer	Square Pharmaceuticals Ltd.
Available Country	Bangladesh
Last Updated:	September 24, 2024 at 5:38 am

Torel (25.40 mg+14.30 mg+4.20 mg+0.05 mg)/gm Muscle Rub

Uses

Muscle pain Sprains, strains and sports injuries, headache bruising, fibrositis, neuralgia, pain due to herpes zoster, osteoarthritis.

The fresh or dried fruits of different Capsicum species are used medicinally. Capsicum oleoresin is prepared by extracting the crushed capsicum with volatile solvents by percolation method. Preparation made from the oleoresin in cayenne and oleoresin's isolated constituent 'Capsaicin' is used as topical analgesic in OTC (over the counter) market. The herb is indigenous to Mexico and Central America. Methyl salicylate, menthol and camphor are originally derived from plants. Methyl salicylate is derived from oil of wintergreen, menthol is derived from mint and camphor is derived from a number of plants including Peppermint, Eucalyptus and Cedar.

Each gm muscle rub contains-

L-Menthol 25.40 mg
D-camphor 14.30 mg
Methyl Salicylate 4.20 mg
Oleoresin Capsicum 0.05 mg

Torel (25.40 mg+14.30 mg+4.20 mg+0.05 mg)/gm Muscle Rub is also used to associated treatment for these conditions: Arthritis, Backache, Common Cold, Contusions, Inflammatory Reaction caused by Insect Bites, Joint Pain, Muscle Cramps, Nasal Congestion, Pain caused by Insect Bites, Rash, Skin Irritation, Soreness, Muscle, Sunburn, Swelling caused by Insect Bites, Minor burns, Neck or back pain, Shoulder acheAcute Muscle Pain, Arthritis, Back Pain Lower Back, Backache, Contusions, Joint Pain, Ligament pain, Muscle Inflammation, Muscle Injuries, Muscle Strain, Muscle swelling, Pain, Pain of the Bone and Bones, Pain, Nerve, Partial-Onset Seizures, Postherpetic Neuralgia, Soreness, Muscle, Sprains, Tendon pain, Minor aches, Muscle, joint pains

How Torel (25.40 mg+14.30 mg+4.20 mg+0.05 mg)/gm Muscle Rub works

Counter-irritation is thought to be effective at alleviating musculoskeletal pain as the irritation of the sensory nerve endings is thought to alter or offset pain in the underlying muscle or joints that are served by the same nerves . This is thought to mask the underlying musculoskeletal pain and discomfort. When applied topically, methyl salicylate is thought to penetrate the skin and underlying tissues where it reversibly inhibits cyclooxygenase enzyme and locally and peripherally prevents the production of inflammatory mediators such as prostaglandin and thromboxane A2.

Dosage

Torel (25.40 mg+14.30 mg+4.20 mg+0.05 mg)/gm Muscle Rub dosage

Adult: Clean the affected area. Apply a small amount of this creamto the surface area of the tip of a finger 3 to 4 times daily or as directed by the physician.

Children under 6 years of age: Not to be used.

In rare cases hypersensitivity reaction may occur. Inhalation of medicine may cause bronchoconstriction.

Toxicity

Oral LD50 values (mg/kg) for mouse, rat and rabbit are 1110, 887 and 1300, respectively. Oral LD50 values for child and adult human (mg/kg) are 228 and 506, respectively. Although systemic toxicity from topical administration is rare, methyl salicylate can be absorbed in intract skin to cause stimulation of the central nervous system respiratory center, disturbance of lipid and carbohydrate metabolism, and disturbance of intracellular respiration. Severe toxicity can result in acute lung injury, lethargy, coma, seizures, cerebral edema, and death. In case of salicylate poisoning, the treatment consists of general supportive care, gastrointestinal decontamination with activated charcoal in cases of salicylate ingestion, and monitoring of serum salicylate concentrations. Bicarbonate infusions or hemodialysis can be used to achieve enhanced salicylate elimination .

Precaution

Avoid use on broken or inflamed skin, eyes and the mucous membranes. Rinse with cold water if accidental contact occurs. Do not cover immediately after application. Wash your hands thoroughly after application. If itching or irritation occurs discontinue it.

Volume of Distribution

After absorption, methyl salicylate is distributed throughout most body tissues and most transcellular fluids, primarily by pH dependent passive processes. Salicylate is actively transported by a low-capacity, saturable system out of the CSF across the choroid plexus. The drug readily crosses the placental barrier.

Elimination Route

Approximately 12-20% of topically applied methyl salicylate may be systemically absorbed through intact skin within 10 hours of application, and absorption varies with different conditions such as surface area and pH. Dermal bioavailability is in the range of 11.8 – 30.7%. For the assessment of potential oral exposure to salicylates, bioavailability is assumed to be 100% .

Half Life

The plasma half-life for salicylate is 2 to 3 hr in low doses and about 12 hr at usual anti-inflammatory doses. The half-life of salicylate may be as long as 15 to 30 hr at high therapeutic doses or when there is intoxication.

Elimination Route

Excreted by kidneys as free salicylic acid (10%), salicyluric acid (75%), salicylic phenolic (10%) and acyl glucuronide (5%), and gentisic acid (less than 1%).

Pregnancy & Breastfeeding use

There is no information available about restriction of this medicine during pregnancy and lactation. May be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks of fetus.

Contraindication

Capsicum preparations are contraindicated for application on injured skin, allergies to aspirin, allergic inflammation of skin, eczema, itchy rash and near the eyes.