Triaminic Night Time Cold & Cough
Triaminic Night Time Cold & Cough Uses, Dosage, Side Effects, Food Interaction and all others data.
Triaminic Night Time Cold & Cough is an alpha-1 adrenergic receptor agonist used to treat hypotension, dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s.
Triaminic Night Time Cold & Cough was granted FDA approval in 1939.
Triaminic Night Time Cold & Cough is an alpha-1 adrenergic agonist that raises blood pressure, dilates the pupils, and causes local vasoconstriction. Ophthalmic formulations of phenylephrine act for 3-8 hours while intravenous solutions have an effective half life of 5 minutes and an elimination half life of 2.5 hours. Patients taking ophthalmic formulations of phenylephrine should be counselled about the risk of arrhythmia, hypertension, and rebound miosis. Patients taking an intravenous formulation should be counselled regarding the risk of bradycardia, allergic reactions, extravasation causing necrosis or tissue sloughing, and the concomitant use of oxytocic drugs.
| Trade Name | Triaminic Night Time Cold & Cough |
| Availability | Rx and/or OTC |
| Generic | Phenylephrine |
| Phenylephrine Other Names | Fenilefrina, Phenylephrine, Phenylephrinum |
| Related Drugs | metoprolol, atenolol, diltiazem, dexamethasone, amiodarone, methylprednisolone, hydrocortisone, bisoprolol, epinephrine topical, epinephrine |
| Type | |
| Formula | C9H13NO2 |
| Weight | Average: 167.205 Monoisotopic: 167.094628665 |
| Protein binding | Data regarding the protein binding of phenylephrine in serum is not readily available. |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Triaminic Night Time Cold & Cough is an alpha-1 adrenergic agonist used in the management of hypotension, generally in the surgical setting associated with the use of anesthetics.
Triaminic Night Time Cold & Cough injections are indicated to treat hypotension caused by shock or anesthesia, an ophthalmic formulation is indicated to dilate pupils and induce vasoconstriction, an intranasal formulation is used to treat congestion, and a topical formulation is used to treat hemorrhoids. Off-label uses include situations that require local blood flow restriction such as the treatment of priapism.
Triaminic Night Time Cold & Cough is also used to associated treatment for these conditions: Allergic Rhinitis (AR), Anorectal discomfort, Cold, Common Cold, Common Cold/Flu, Congestion of the Conjunctivas, Conjunctivitis allergic, Cough, Cough caused by Common Cold, Eye allergy, Eye redness, Fever, Flu caused by Influenza, Headache, Headache caused by Allergies, Headache caused by Common Cold, Headache caused by Pollen Allergy, Hemorrhoids, Hypotension, Irritative cough, Itching of the nose, Itching of the throat, Laryngotracheitis, Nasal Congestion, Nose discomfort, Ocular Inflammation, Ocular Irritation, Paroxysmal Supraventricular Tachycardia, Pollen Allergy, Respiratory tract congestion, Respiratory tract irritation, Rhinopharyngitis, Rhinorrhoea, Seasonal Allergies, Shock, Cardiogenic, Sinus Congestion, Sinus pressure, Sinusitis, Sneezing, Sore Throat, Tracheobronchitis, Upper respiratory tract hypersensitivity reaction, site unspecified, Vasomotor Rhinitis, Aching caused by Flu caused by Influenza, Bronchial congestion, Itchy throat, Minor aches and pains, Watery itchy eyes, Airway secretion clearance therapy, Antihistamine, Dilatation of the pupil, Vasoconstrictor in regional analgesia therapy
How Triaminic Night Time Cold & Cough works
Triaminic Night Time Cold & Cough is an alpha-1 adrenergic agonist that mediates vasoconstriction and mydriasis depending on the route and location of administration. Systemic exposure to phenylephrine also leads to agonism of alpha-1 adrenergic receptors, raising systolic and diastolic pressure as well as peripheral vascular resistance. Increased blood pressure stimulates the vagus nerve, causing reflex bradycardia.
Toxicity
Patients experiencing and overdose may present with headache, hypertension, reflex bradycardia, tingling limbs, cardiac arrhythmias, and a feeling of fullness in the head. Overdose may be treated by supportive care and discontinuing phenylephrine, chronotropic medications, and vasodilators. Subcutaneous phentolamine may be used to treat tissue extravasation.
Food Interaction
No interactions found.Triaminic Night Time Cold & Cough Drug Interaction
Moderate: duloxetineUnknown: fexofenadine, diphenhydramine, loratadine, ubiquinone, dextromethorphan, omega-3 polyunsaturated fatty acids, cyclobenzaprine, fluticasone nasal, pregabalin, guaifenesin, acetaminophen, montelukast, acetaminophen, cyanocobalamin, ascorbic acid, cholecalciferol, alprazolam, ondansetron, cetirizine
Triaminic Night Time Cold & Cough Disease Interaction
Major: cardiovascular diseaseModerate: BPH, diabetes, glaucoma
Volume of Distribution
The volume of distribution of phenylephrine is 340L.
Elimination Route
Triaminic Night Time Cold & Cough is 38% orally bioavailable. Clinically significant systemic absorption of ophthalmic formulations is possible, especially at higher strengths and when the cornea is damaged.
Half Life
Intravenous phenylephrine has an effective half life of 5 minutes and an elimination half life of 2.5 hours.
Clearance
Triaminic Night Time Cold & Cough has an average clearance of 2100mL/min.
Elimination Route
86% of a dose of phenylephrine is recovered in the urine with 16% as the unmetabolized drug, 57% as the inactive meta-hydroxymendelic acid, and 8% as inactive sulfate conjugates.
Innovators Monograph
You find simplified version here Triaminic Night Time Cold & Cough
FAQ
What is Triaminic Night Time Cold & Cough used for?
Triaminic Night Time Cold & Cough is a medication primarily used as a decongestant, to dilate the pupil, to increase blood pressure, and to relieve hemorrhoids. When taken orally as a decongestant, it relieves nasal congestion due to colds and hay fever.
How safe is Triaminic Night Time Cold & Cough?
Triaminic Night Time Cold & Cough is approved by the U.S. Food and Drug Administration (FDA) and is safe and effective when used according to the Drug Facts label.
How does Triaminic Night Time Cold & Cough work?
Triaminic Night Time Cold & Cough works by directly stimulating alpha-1 adrenergic receptors in the arteries causing vasoconstriction.
What are the common side effects of Triaminic Night Time Cold & Cough?
Mild upset stomach, trouble sleeping, dizziness, lightheadedness, headache, nervousness, shaking, or fast heartbeat may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. This product may reduce blood flow to your hands or feet, causing them to feel cold.
Is Triaminic Night Time Cold & Cough safe during pregnancy?
Triaminic Night Time Cold & Cough that's taken by mouth is not safe for pregnant women. Triaminic Night Time Cold & Cough are generally not recommended during the first 13 weeks of pregnancy.
Is Triaminic Night Time Cold & Cough safe during breastfeeding?
Triaminic Night Time Cold & Cough an ingredient in pediatric cough and cold preparations, is considered safe. While excretion into breast milk is unknown, it is unlikely to be excreted into breast milk in large quantities due to its poor bioavailability.
Can I drink alcohol with Triaminic Night Time Cold & Cough?
Do not drink alcohol while taking this medication. Drinking alcohol while taking this medication can cause confusion, dizziness, lightheadedness, and increased risk of falling
Can I drink alcohol with Triaminic Night Time Cold & Cough?
This Triaminic Night Time Cold & Cough may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Drinking alcohol can increase certain side effects of chlorpheniramine and Triaminic Night Time Cold & Cough.
How often can I take Triaminic Night Time Cold & Cough?
Triaminic Night Time Cold & Cough is usually taken every 4 hours as needed.
Can I take Triaminic Night Time Cold & Cough on an empty stomach?
Take this Triaminic Night Time Cold & Cough by mouth with or without food or as directed by your doctor. Taking it with food may decrease stomach upset.
How long does Triaminic Night Time Cold & Cough take to work?
The decongestant effect of Triaminic Night Time Cold & Cough in cold or flu remedies should be noticeable within 15 to 30 minutes, and the effects last less than 4 hours. A rapid increase in blood pressure is usually seen following an intravenous dose that persists for up to 20 minutes.
How long does Triaminic Night Time Cold & Cough stay in my system?
The elimination half life of Triaminic Night Time Cold & Cough is about 2.5 to 3.0 hours. The clinical effects of a single intravenous bolus dose of Triaminic Night Time Cold & Cough are short lived and needs to be repeated every 10–15 minutes.
How long can I take Triaminic Night Time Cold & Cough?
This Triaminic Night Time Cold & Cough is for temporary use only. Do not use for more than 7 days in a row without first consulting your doctor. Triaminic Night Time Cold & Cough nasal is usually used every 4 hours.
When should I stop taking Triaminic Night Time Cold & Cough?
Stop using Triaminic Night Time Cold & Cough and call your doctor at once if you have: fast, pounding, or irregular heartbeat; severe dizziness or nervousness; sleep problems (insomnia).
Who should not take Triaminic Night Time Cold & Cough?
Do not use Triaminic Night Time Cold & Cough if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.
What happens if I miss a dose?
Since cold medicine is used when needed, you may not be on a dosing schedule. Skip any missed dose if it's almost time for your next dose. Do not use two doses at one time.
What happen if I take too much Triaminic Night Time Cold & Cough?
Taking too much Triaminic Night Time Cold & Cough can be dangerous. It can make you restless or your heartbeat fast, and make you feel sick or vomit. You may also have difficulty peeing.
Will Triaminic Night Time Cold & Cough affect my fertility?
Triaminic Night Time Cold & Cough or pseudophedrine have any impact on fertility.
Does Triaminic Night Time Cold & Cough cause heart palpitations?
Triaminic Night Time Cold & Cough can cause heart palpitations or raise your blood pressure.
Can Triaminic Night Time Cold & Cough affect my kidneys?
Triaminic Night Time Cold & Cough can increase blood pressure and cause your heart and kidneys to work too hard.
