Paget’s Disease
What is Paget’s Disease?
Paget’s Disease is a disorder of bone remodeling, described as accelerated destruction and formation of bone that occurs in areas outside of normal growth areas. Normally, bone cells work together in a well-coordinated process that maintains bone density and strength. In Paget's disease, this process is thrown off balance, causing abnormal bone growth that can lead to deformity, pain, and increases in risk of fracture.
Signs and Symptoms
The most common symptoms of Paget’s Disease are joint pain, tenderness, and stiffness. Other symptoms include:
- Loss of bone density
- Bone fractures
- Deformity of bones
- Headache
- Numbness
- Tingling
- Hearing loss
Treatment for Paget’s Disease
The primary goal of treating Paget’s Disease is to reduce pain and prevent fractures. Treatment may include medications, physiotherapy, and, in some cases, surgery. The type of treatment will depend on the severity of the condition and the symptoms present. Commonly-used medications include:
- Non-steroidal anti-inflammatory drugs (NSAIDs) to reduce pain and inflammation.
- Corticosteroids to reduce inflammation.
- Bisphosphonates to reduce bone breakdown and re-establish normal bone growth.
- Calcium and vitamin D supplements to promote bone health.
Summary
Paget’s Disease is a chronic disorder that affects the bones, causing abnormal growth that can lead to pain, stiffness, and increased risk of fractures. Treatment for Paget’s Disease depends on the severity of the symptoms and can include medications, physiotherapy, and, in some cases, surgery.