0.5% Mepivacaine Hydrochloride PB
0.5% Mepivacaine Hydrochloride PB Uses, Dosage, Side Effects, Food Interaction and all others data.
A local anesthetic that is chemically related to bupivacaine but pharmacologically related to lidocaine. It is indicated for infiltration, nerve block, and epidural anesthesia. 0.5% Mepivacaine Hydrochloride PB is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)
Mepivicaine is an amide local anesthetic. Mepivicaine as a reasonably rapid onset and medium duration and is known by the proprietary names as Carbocaine and Polocaine. Mepivicaine is used in local infiltration and regional anesthesia. Systemic absorption of local anesthetics produces effects on the cardiovascular and central nervous systems. At blood concentrations achieved with normal therapeutic doses, changes in cardiac conduction, excitability, refractoriness, contractility, and peripheral vascular resistance are minimal.
| Trade Name | 0.5% Mepivacaine Hydrochloride PB |
| Availability | Prescription only |
| Generic | Mepivacaine |
| Mepivacaine Other Names | DL-Mepivacaine, Mepivacaina, Mepivacaine, Mepivacainum |
| Related Drugs | lidocaine ophthalmic, cocaine nasal, bupivacaine |
| Type | |
| Formula | C15H22N2O |
| Weight | Average: 246.348 Monoisotopic: 246.173213336 |
| Protein binding | Mepivacaine is approximately 75% bound to plasma proteins. Generally, the lower the plasma concentration of drug, the higher the percentage of drug bound to plasma. |
| Groups | Approved, Vet approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | Japan |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
0.5% Mepivacaine Hydrochloride PB is a local anesthetic used for local or regional analgesia or anesthesia.
For production of local or regional analgesia and anesthesia by local infiltration, peripheral nerve block techniques, and central neural techniques including epidural and caudal blocks.
0.5% Mepivacaine Hydrochloride PB is also used to associated treatment for these conditions: Anaemia vitamin B6 deficiency, Anemia, Blood Loss Anemia, Diabetic Peripheral Neuropathy (DPN), Regional nerve block therapy, Local anesthesia therapy, Lumbar epidural anesthesia therapy
How 0.5% Mepivacaine Hydrochloride PB works
Local anesthetics block the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. In general, the progression of anesthesia is related to the diameter, myelination, and conduction velocity of affected nerve fibers. Clinically, the order of loss of nerve function is as follows: pain, temperature, touch, proprioception, and skeletal muscle tone.
Toxicity
The mean seizure dosage of mepivacaine in rhesus monkeys was found to be 18.8 mg/kg with mean arterial plasma concentration of 24.4 µg/mL. The intravenous and subcutaneous LD 50 in mice is 23 mg/kg to 35 mg/kg and 280 mg/kg respectively.
Food Interaction
No interactions found.0.5% Mepivacaine Hydrochloride PB Drug Interaction
Major: bupivacaine, bupivacaineUnknown: duloxetine, duloxetine, glucose, glucose, diltiazem, diltiazem, metoprolol, metoprolol, metoprolol, metoprolol, chlorhexidine topical, chlorhexidine topical, articaine / epinephrine, articaine / epinephrine, acetaminophen, acetaminophen, acetaminophen / codeine, acetaminophen / codeine
0.5% Mepivacaine Hydrochloride PB Disease Interaction
Elimination Route
Absorbed locally. The rate of systemic absorption of local anesthetics is dependent upon the total dose and concentration of drug administered, the route of administration, the vascularity of the administration site, and the presence or absence of epinephrine in the anesthetic solution.
Half Life
The half-life of mepivacaine in adults is 1.9 to 3.2 hours and in neonates 8.7 to 9 hours.
Elimination Route
It is rapidly metabolized, with only a small percentage of the anesthetic (5 percent to 10 percent) being excreted unchanged in the urine.The liver is the principal site of metabolism, with over 50% of the administered dose being excreted into the bile as metabolites.
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