11C-choline Chloride
11C-choline Chloride Uses, Dosage, Side Effects, Food Interaction and all others data.
11C-choline Chloride is a marker for cellular proliferation as its main molecule is a precursor for the biosynthesis of phospholipids which are essential components of all cell membranes. It was developed by MCPRF and FDA first approved in September 2012.
Choline is phosphorylated by choline kinase into phosphorylcholine. This phosphorylated form gets trapped inside the cell. Cancer cells exhibit an increased cell wall membrane synthesis as well as an increased activity of choline kinase. Choline C11 presents a small tracer activity in the urinary collecting system and this property makes it a very noble compound in the evaluation of ureters and bladder.
| Trade Name | 11C-choline Chloride |
| Generic | Choline C 11 |
| Choline C 11 Other Names | 11C-choline, 11C-choline chloride |
| Type | |
| Formula | C5H14ClNO |
| Weight | Average: 138.62 Monoisotopic: 138.0878256 |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Choline C11 is indicated for its use in positron emission tomography (PET) imaging in patients with suspected prostate cancer recurrence and non-informative bone scintigraphy, computerized tomography or magnetic resonance imaging.
How 11C-choline Chloride works
Choline is incorporated into phosphatidylcholine which is a major membrane phospholipid in mammalian cells. The use of choline C11 is based on the knowledge that malignant tumors with increased cellular proliferation take up more choline when compared with normal cells for the formation of cellular membranes. The increased uptake of choline is explained by its use as a substrate in phospholipid synthesis in cell membranes, transmembrane signaling, and lipid and cholesterol transport and metabolism.
Toxicity
Choline is a natural compound with no known toxic effects at the levels administered in the form of choline C11. The carcinogenic effect of choline C11 has not been determined in long-term studies.
Elimination Route
The highest normal tissue uptake is seen in renal cortex, liver, pancreas and salivary glands. It presents a variable bowel, prostate and pituitary uptake and a low uptake in the cerebral cortex. The short half-life of choline C11 limits the availability and it is recommended to be delivered within 2-3 half-lives from producing cyclotron.
Half Life
The isotope half-life of choline C11 is 20.4 min.
Clearance
After intravenous injection, choline C11 is rapidly cleared from the bloodstream. The clearance rate of choline C11 is or 0.014 ml/min.
Elimination Route
Choline 11 presents a minimal urinary excretion and it represents 2 After intravenous administration, choline C11 gets rapidly cleared from the circulation (5 The oxidation metabolite of choline, named betaine, is excreted into the urine.
Innovators Monograph
You find simplified version here 11C-choline Chloride
