12-dien-16-oic Acid γ-Lactone
12-dien-16-oic Acid γ-Lactone Uses, Dosage, Side Effects, Food Interaction and all others data.
12-dien-16-oic Acid γ-Lactone (HMPL-004) is a botanical product extracted from a herb that occurs naturally in China. The herb has an extensive history of use in TCM for the treatment of upper respiratory tract infections and other inflammatory and infectious diseases.
| Trade Name | 12-dien-16-oic Acid γ-Lactone |
| Generic | Andrographolide |
| Andrographolide Other Names | 3α,14,15,18-tetrahydroxy-5b,9bH,10a-labda-8(20),12-dien-16-oic acid γ-Lactone |
| Type | |
| Formula | C20H30O5 |
| Weight | Average: 350.455 Monoisotopic: 350.209324066 |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Investigated for use/treatment in ulcerative colitis.
How 12-dien-16-oic Acid γ-Lactone works
HMPL-004 acts on multiple cellular targets in the inflammatory signal transduction pathways resulting in suppressed inflammation cytokine expression including TNF-α, IL-1β and IL-6. HMPL-004 was demonstrated to inhibit TNF-α and IL-1β production in cell-based assays. HMPL-004 is also able to inhibit NF-kB activation. NF-kB is a family of transcriptional factors that regulate a wide spectrum of genes critically involved in host defence and inflammation. The mechanism of action of HMPL-004 was further supported in laboratory IBD animal models. Treatment of IBD rats with HMPL-004 caused a significant drop in plasma cytokine concentrations, including TNF-α and IL-1β.
Innovators Monograph
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