(18F)-Fluoride
(18F)-Fluoride Uses, Dosage, Side Effects, Food Interaction and all others data.
Sodium Fluoride F 18 Injection is a positron emitting radiopharmaceutical, no-carrier added. It contains radioactive fluoride F 18 that is used for diagnostic purposes in conjunction with positron emission tomography (PET) imaging and is administered by intravenous injection. Its primary indication is for bone imaging. Increased deposition around joints can occur in arthritis and following trauma and increased deposition in bone has been noted around fracture sites, in osteomyelitis, fibrous dysplasia, spondylitis tuberculosa, and Paget's disease. No adverse reactions have been reported.
Deposition of 18F fluoride in bone appears to be primarily a function of blood flow to the bone and the efficiency of the bone in extracting the 18F from the blood perfusing the bone. Increased fluorine F 18 ion deposition around joints can occur in arthritis or following trauma; increased deposition has also been documented in bone around fracture sites, in osteomyelities, fibrous dysplasia, spondylitis tuberculosa, Paget's disease, hyperstosis frontalis interna, myositis, ossificans, and in rapidly growing epiphyses. The tendency for fluorine F 18 ions to accumulate in the vicinity of primary and metastatic malignancy in bone has proven clinically useful in detection of such lesions
| Trade Name | (18F)-Fluoride |
| Generic | Fluoride ion F-18 |
| Fluoride ion F-18 Other Names | (18F)-Fluoride, 18F-Fluoride, Fluoride-18 anion |
| Type | |
| Formula | F |
| Weight | Average: 18.0015 Monoisotopic: 18.001486247 |
| Protein binding | Fluorine F 18 ions do not appear to be bound to serum proteins |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
(18F)-Fluoride is a diagnostic radiopharmaceutical agent used as a bone imaging agent to delineate areas of altered osteogenesis.
18F is used as a bone imaging agent to define areas of altered osteogenic activity. It has been indicated for back pain and otherwise unexplained bone pain, child abuse, abnormal radiographic or laboratory findings, osteomyelitis, trauma, inflammatory and degenerative arthritis, avascular necrosis. Osteonecrosis of the mandible, condylar hyperplasia, and metabolic bone disease are also among the indications for fluoride imaging.
(18F)-Fluoride is also used to associated treatment for these conditions: Altered osteogenesis, Altered osteogenic activity
How (18F)-Fluoride works
18F-fluoride is a highly sensitive bone-seeking PET tracer used for detection of skeletal abnormalities. The uptake mechanism of 18F-fluoride has better pharmacokinetic characteristics (compared to other elements) including faster blood clearance and 2-fold higher uptake in bone. Uptake of 18F-fluoride reflects blood flow and bone remodeling.
Toxicity
The lethal dose of NaF to the average adult has been estimated to be between 32 to 64 mg fluoride/kg body weight.
Food Interaction
No interactions found.Volume of Distribution
0.5-0.7 L/Kg
Elimination Route
Following intravenous administration, Sodium Fluoride F 18 injection provides fluorine F 18 ions that rapidly equilibrate, primarily within the extracellular fluid space.
Half Life
110 min.
Clearance
Renal clearance for fluoride is 48-147 mL/min, depending upon urinary flow and pH.
Elimination Route
Fluorine F 18 ions are rapidly eliminated via the renal system. 20% or more of the fluorine F 18 ions are cleared from the body in the urine within the first 2 hours after intravenous administration.
Innovators Monograph
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