2-hydroxyethyl Salicylate

2-hydroxyethyl Salicylate Uses, Dosage, Side Effects, Food Interaction and all others data.

2-hydroxyethyl Salicylate, also known as 2-hydroxyethyl salicylate, is a benzoate ester formed from the condensation of the carboxy group of salicylic acid with one of the hydroxy groups of ethylene glycol. It is found as an active ingredient and topical analgesic in patches used to provide relief for mild to moderate muscle and joint pain .

This drug belongs to the salicylate group of drugs, which are used as analgesic agents for the treatment of mild to moderate pain .

2-hydroxyethyl Salicylate (GS), composed of salicylic acid (SA) and ethylene glycol, is a non-steroidal anti-inflammatory drug .

2-hydroxyethyl Salicylate
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
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Trade Name	2-hydroxyethyl Salicylate
Generic	Glycol salicylate
Glycol salicylate Other Names	2-hydroxyethyl salicylate, Ethylene glycol monosalicylate, Ethylene glycol salicylate, Glycol salicylate
Type
Formula	C₉H₁₀O₄
Weight	Average: 182.175 Monoisotopic: 182.057908802
Protein binding	The plasma protein binding of salicylic acid is concentration-dependent and subject to pronounced interindividual differences .
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

2-hydroxyethyl Salicylate is a salicylate used to treat mild to moderate muscle pain.

This drug is only recommended for topical usages for the relief of muscular and rheumatic pain in human and animals .

2-hydroxyethyl Salicylate is also used to associated treatment for these conditions: Back Pain Lower Back, Chilblains, Contusions, Joint Pain, Pain caused by Fracture Bone, Soreness, Muscle, Sprains, Stiff Shoulder

How 2-hydroxyethyl Salicylate works

Similar to other salicylates. Salicylates and other analgesics and anti-inflammatory drugs, particularly the non-steroidal anti-inflammatory drugs (NSAID) mainly used in rheumatology, inhibit cyclooxygenase, therefore reducing prostaglandin synthesis .

Toxicity

Acute ingestion of > 150 mg/kg of salicylates may result in severe toxicity. Salicylate tablets may form stomach bezoars, prolonging absorption of the drug and toxicity. Chronic toxicity can occur after several days or more of high therapeutic doses; it is common, often undiagnosed, and often more serious than acute toxicity. Chronic toxicity is likely to occur in elderly patients .

Treatment for salicylate poisoning consists of activated charcoal and alkaline diuresis with extra KCl .

Unless contraindicated (eg, by altered mental status), activated charcoal is administered as soon as possible and, if bowel sounds are active and there is adequate gastrointestinal motility, may be repeated every 4 hours until charcoal appears in the stool .

After volume and electrolyte abnormalities are corrected and maintained, alkaline diuresis can be used to increase urine pH, ideally to ≥ 8. Alkaline diuresis is advised for patients with any symptoms of poisoning and should not be delayed until salicylate levels are determined. This process is usually safe and greatly increases the rate of salicylate excretion. Because hypokalemia can interfere with alkaline diuresis, patients are often given a solution composed of 1 L of 5% D/W, 3 50-mEq ampules of NaHCO3, and 40 mEq of KCl at 1.5 to 2 times the maintenance IV fluid rate. Serum potassium levels are monitored. Due to the fact that fluid overload can lead to the occurrence of pulmonary edema, patients are monitored for respiratory findings .

Drugs that increase urinary HCO3 (eg, acetazolamide) must be avoided because they worsen metabolic acidosis and decrease blood pH. Drugs that decrease respiratory drive should be avoided when possible because they may impair hyperventilation and respiratory alkalosis, decreasing blood pH .