2-Methoxyestradiol-17beta
2-Methoxyestradiol-17beta Uses, Dosage, Side Effects, Food Interaction and all others data.
2-Methoxyestradiol-17beta (2ME2) is a drug that prevents the formation of new blood vessels that tumors need in order to grow (angiogenesis). It has undergone Phase 1 clinical trials against breast cancers and preclinical studies suggest that 2ME2 could also be effective against inflammatory diseases such as rheumatoid arthritis.
2-Methoxyestradiol-17beta belongs to the family of drugs called angiogenesis inhibitors. It also acts as a vasodilator.
| Trade Name | 2-Methoxyestradiol-17beta |
| Generic | 2-Methoxyestradiol |
| 2-Methoxyestradiol Other Names | 2-ME2, 2-Methoxyestradiol-17beta, 2ME2 |
| Type | |
| Formula | C19H26O3 |
| Weight | Average: 302.4079 Monoisotopic: 302.188194698 |
| Protein binding | 2ME2 was found to bind in decreasing order to plasma>albumin>alpha1-acid glycoprotein>sex-hormone-binding globulin. Plasma concentration-time profiles of total 2ME2 and unbound 2ME2 concentrations in a patient with cancer receiving 2ME2 as a single oral dose were parallel to each other. Thus, indicating that plasma protein binding is not an important consideration in pharmacokinetic monitoring of 2ME2. |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
For the treatment of breast cancer and inflammatory diseases such as rheumatoid arthritis.
How 2-Methoxyestradiol-17beta works
2-Methoxyestradiol-17beta is an angiogenesis inhibitor, and has been shown to attack both tumor cells and their blood supply in preclinical testing. 2-methoxyestradiol is a naturally occurring estrogen metabolite but has no undesired estrogenic activity.
Innovators Monograph
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