309 Fourneau

309 Fourneau Uses, Dosage, Side Effects, Food Interaction and all others data.

A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties. 309 Fourneau is manufactured by Bayer in Germany as Germanin®.

Table Of contents

• 309 Fourneau
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	309 Fourneau
Generic	Suramin
Suramin Other Names	Suramin, Suramine
Type
Formula	C51H40N6O23S6
Weight	Average: 1297.28 Monoisotopic: 1296.046905756
Protein binding	Approximately 99.7%
Groups	Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

For treatment of human sleeping sickness, onchocerciasis and other diseases caused by trypanosomes and worms.

How 309 Fourneau works

The mechanism is unknown, but the trypanocidal activity may be due to the inhibition of enzymes involved with the oxidation of reduced nicotinamide-adenine dinucleotide (NADH), which functions as a co-enzyme in many cellular reactions, such as respiration and glycolysis, in the trypanosome parasite. 309 Fourneau's action in the treatment of onchocerciasis is macrofilaricidal and partially microfilaricidal. It may also act as an antagonist of P2 receptors and as an agonist of Ryanodine receptors. It also can inhibit follicle-stimulating hormone receptors.

Elimination Route

Poorly absorbed from the gastrointestinal tract.

Half Life

Approximately 36 to 60 days

Innovators Monograph

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