4-hydroxyphenyl Retinamide
4-hydroxyphenyl Retinamide Uses, Dosage, Side Effects, Food Interaction and all others data.
A synthetic retinoid that is used orally as a chemopreventive against prostate cancer and in women at risk of developing contralateral breast cancer. It is also effective as an antineoplastic agent.
| Trade Name | 4-hydroxyphenyl Retinamide |
| Generic | Fenretinide |
| Fenretinide Other Names | 4-hydroxyphenyl retinamide, Fenretinida, Fenretinide, Fenretinidum |
| Type | |
| Formula | C26H33NO2 |
| Weight | Average: 391.5457 Monoisotopic: 391.251129305 |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Investigated for use/treatment in macular degeneration.
How 4-hydroxyphenyl Retinamide works
4-hydroxyphenyl Retinamide inhibits the growth of several human cancer cell lines, acting through both retinoid-receptor-dependent and retinoid-receptor-independent mechanisms.1In vivo, fenretinide selectively accumulates in breast tissue and is particularly active in inhibiting rat mammary carcinogenesis.1 An important feature of fenretinide is its ability to inhibit cell growth through the induction of apoptosis rather than through differentiation, an effect that is strikingly different from that of vitamin A.1 In contrast to tamoxifen, which inhibits only estrogen receptor (ER)-positive tumors, fenretinide induces apoptosis in both ER-positive and ER-negative breast cancer cell lines.2 All of these properties render fenretinide an attractive candidate for breast cancer chemoprevention.
Toxicity
"Mechanism of fenretinide (4-HPR)-induced cell death"
Innovators Monograph
You find simplified version here 4-hydroxyphenyl Retinamide
