4F-PCC
4F-PCC Uses, Dosage, Side Effects, Food Interaction and all others data.
Factor IX Complex is a sterile, lyophilized concentrate composed of a number of Vitamin K-dependent clotting factors found in functioning human plasma. Also known as prothrombin complex concentrate, products containing this complex often include Factor IX (antihemophilic factor B), Factor II (prothrombin), Factor X (Stuart-Prower Factor), and low levels of Factor VII (proconvertin) derived from human plasma. Many commercially available products also contain low levels of other antithrombotic proteins. For example, Kcentra (FDA) also contains the antithrombotic proteins C and S, while Bebulin VH (FDA) contains heparin. Coagulation factors are purified from pooled human plasma and subsequently sterilized and treated.
Although Factor IX Complex products contain many different coagulation components, Factor IX is the lead component for potency and efficacy, particularly when used for the treatment of bleeding associated with Hemophilia B (Factor IX deficiency). As the product Kcentra, Factor IX Complex is also indicated for the urgent reversal of acquired coagulation factor deficiency induced by Vitamin K antagonist (VKA, e.g., warfarin) therapy in adult patients experiencing acute major bleeding or requiring rapid reversal of therapy.
| Trade Name | 4F-PCC |
| Generic | Factor IX Complex (Human) |
| Factor IX Complex (Human) Other Names | 4F-PCC, APCC, Coagulation factor IX complex human, Coagulation factor IX, II, VII and X in combination, Factor IX Complex, Factor IX Complex (Human), Factor IX complex human, Factor IX complex,human, Factor IX Fraction, PCC, Plasma Concentrate Factor IX, Prothrombin complex concentrate, Prothrombin complex concentrate (human) |
| Type | |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
4F-PCC is a Factor IX complex used to prevent and treat bleeding episodes in hemophilia B or vitamin K antagonist therapy.
Factor IX Complex is indicated for the prevention and control of hemorrhagic episodes in hemophilia B patients. It is also indicated for the urgent reversal of acquired coagulation factor deficiency induced by Vitamin K antagonist (VKA, e.g., warfarin) therapy in adult patients with acute major bleeding or who require rapid reversal of therapy.
4F-PCC is also used to associated treatment for these conditions: Bleeding, Hemorrhage, Intracranial Hemorrhages, Perioperative bleeding management
How 4F-PCC works
Factor IX Complex is a sterile, lyophilized concentrate composed of a number of Vitamin K-dependent clotting factors found in functioning human plasma. Also known as prothrombin complex concentrate, products containing this complex often include Factor IX (antihemophilic factor B), Factor II (prothrombin), Factor X (Stuart-Prower Factor), and low levels of Factor VII (proconvertin) derived from human plasma. Many commercially available products also contain low levels of other antithrombotic proteins. For example, Kcentra(FDA) also contains the antithrombotic proteins C and S, while Bebulin VH (FDA) contains heparin.
This complex of coagulation factors helps replenish clotting factors that may have been lost through warfarin therapy or through a congenital abnormality such as Hemophilia B.
Food Interaction
No interactions found.Innovators Monograph
You find simplified version here 4F-PCC
