8-Bromotheophylline

8-Bromotheophylline Uses, Dosage, Side Effects, Food Interaction and all others data.

8-Bromotheophylline is the active moiety of pamabrom, a mixture of 2-amino-2-methyl-propanol and bromotheophylline. From this mixture, bromotheophylline acts as a weak diuretic that has been used along with some analgesics to relieve the symptoms of premenstrual syndrome. 8-Bromotheophylline is categorized on the FDA as a drug substance with an inactive state since March, 1980. It is also approved by Health Canada to be used alone or in combination with Acetaminophen in OTC products.

8-Bromotheophylline diuretic action will produce an immediate increase in urination frequency. This effect aids in the relief of bloating and menstrual pain. This diuretic function is performed by the an increase in glomerular filtration and a potential effect in the tubular reabsorption as it is established that the administration of these agents produce a rise in the urinary concentration of sodium a chloride and thus, an increase in their rates of excretion.

8-Bromotheophylline
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	8-Bromotheophylline
Generic	Bromotheophylline
Bromotheophylline Other Names	8-Bromotheophylline
Type
Formula	C₇H₇BrN₄O₂
Weight	Average: 259.063 Monoisotopic: 257.975238
Protein binding	This pharmacokinetic property has not been determined.
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

8-Bromotheophylline is used as a diuretic and also, in combination with Acetaminophen, it is used for the relief of temporary water weight gain, bloating, swelling and full feeling associated with the premenstrual and menstrual periods.

8-Bromotheophylline is also used to associated treatment for these conditions: Premenstrual Syndrome, Menstrual syndrome, Water retention

How 8-Bromotheophylline works

8-Bromotheophylline is part of the group of the xanthines. As part of this group, it is thought that bromotheophylline increases the permeability of the renal tubule, increases glomerular filtration rate and inhibits the sodium reabsorption in the proximal tubule. It is thought but not confirmed that pamabrom as a mixture seems to have an additional mechanism of action in which the presence of 2-amino-2-methyl-1-propanol produces the suppression of the antidiuretic hormone in the posterior pituitary gland.

Toxicity

In overdose, bromotheophylline does not produce hepatic toxicity.

Food Interaction

Drink plenty of fluids. Avoid dehydration by drinking 6-8 glasses of water daily.
Take with a full glass of water.

Volume of Distribution

This pharmacokinetic property has not been determined.

Elimination Route

When administered after one single oral dosage, bromotheophylline is rapidly absorbed and it reaches a maximal plasma concentration of 2.5 mg/L in 0.78 hours. The mean residence time is registered to be of 12 hours with an AUC in the first 8 hours of 27 mg.h/L.