(99m)Tc HM-PAO
(99m)Tc HM-PAO Uses, Dosage, Side Effects, Food Interaction and all others data.
(99m)Tc HM-PAO is a radiopharmaceutical sold under the trade name Ceretec used in the detection of altered regional cerebral perfusion in stroke and other cerebrovascular diseases. It can also be used for the labelling of leukocytes to localise intra-abdominal infections and inflammatory bowel disease. Exametazime, also known as hexamethylpropyleneamine oxime or HMPAO, acts as a chelating agent for the Tc-99m radioisotope.
During the first hour following injection of Tc99m labeled leukocytes, activity is seen in the lungs, liver, spleen, blood pool, bone marrow and the bladder. The kidneys (parenchyma and/or renal pelvis) and gall bladder may also be visualized. Over the first 1-6 hours, the Tc99m is visualized in the bowel. At 24 hours post-injection substantial colonic activity is seen.
| Trade Name | (99m)Tc HM-PAO |
| Generic | Technetium Tc-99m exametazime |
| Technetium Tc-99m exametazime Other Names | (99m)Tc HM-PAO, (99m)Tc HMPAO, [(99m)Tc] HM-PAO, Technetium (99mTc) exametazime, Technetium (99mTc) HMPAO, Technetium tc 99m exametazime, Technetium tc 99m HMPAO, Technetium Tc-99m exametazime |
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| Groups | Approved |
| Therapeutic Class | |
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| Last Updated: | September 19, 2023 at 7:00 am |
Uses
(99m)Tc HM-PAO is a radiopharmaceutical diagnostic agent used as an adjunct for scintigraphy in the detection of altered regional cerebral perfusion in stroke.
Technetium Tc99m exametazime scintigraphy (with or without methylene blue stabilization) may be useful as an adjunct in the detection of altered regional cerebral perfusion in stroke. Tc99m exametazime without methylene blue stabilization is indicated for leukocyte labeled scintigraphy as an adjunct in the localization of intra-abdominal infection and inflammatory bowel disease.
(99m)Tc HM-PAO is also used to associated treatment for these conditions: Inflammatory Bowel Diseases (IBD), Intra-Abdominal Infections, Altered regional cerebral perfusion in stroke
Food Interaction
No interactions found.Volume of Distribution
The activity not associated with the brain is widely distributed throughout the body, particularly in muscle and soft tissue.
Elimination Route
(99m)Tc HM-PAO is rapidly cleared from the blood after intravenous injection. Uptake in the brain reaches a maximum of 3.5-7.0% of the injected dose within one minute of injection. Up to 15% of the activity is eliminated from the brain by 2 minutes post injection, after which little activity is lost for the following 24 hours except by physical decay of technetium Tc99m.
Elimination Route
About 30% of the injected dose is found in the gastrointestinal tract immediately after injection and about 50% of this is excreted through the intestinal tract over 48 hours. Also, about 40% of the injected dose is excreted through the kidneys and urine over the 48 hours after injection.
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