Amoebyl

Amoebyl Uses, Dosage, Side Effects, Food Interaction and all others data.

Amoebyl (as Amoebyl furoate) is an anti-protozoal drug used in the treatment of Entamoeba histolytica and some other protozoal infections. Although it is not currently approved for use in the United States, it was approved by a CDC study in the treatment of 4,371 cases of Entamoeba histolytica from 1977 to 1990.

Amoebyl is a luminal amebicide, however the mechanism of action of diloxanide is unknown. Amoebyl destroys the trophozoites of E. histolytica that eventually form into cysts. The cysts are then excreted by persons infected with asymptomatic amebiasis. Amoebyl furoate is a prodrug, and is hydrolyzed in the gastrointestinal tract to produce diloxanide, the active ingredient.

Trade Name Amoebyl
Generic Diloxanide
Diloxanide Other Names Diloxanide
Type
Formula C9H9Cl2NO2
Weight Average: 234.08
Monoisotopic: 233.0010339
Groups Experimental
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Amoebyl
Amoebyl

Uses

Amoebyl is used alone as a primary agent in the treatment of asymptomatic (cyst passers) intestinal amebiasis caused by Entamoeba histolytica. Amoebyl may also be used concurrently, or sequentially, with other agents such as the nitroimidazoles (eg. metronidazole) in the treatment of invasive or extraintestinal forms of amebiasis.

How Amoebyl works

Unknown. Amoebyl may inhibit protein synthesis.

Elimination Route

Bioavailability is 90% (in diloxanide parental form), however diloxanide furoate is slowly absorbed from the gastrointestinal tract.

Half Life

3 hours

Elimination Route

Renal (90%, rapidly excreted as glucuronide metabolite). 10% is excreted in the feces as diloxanide.

Innovators Monograph

You find simplified version here Amoebyl

*** Taking medicines without doctor's advice can cause long-term problems.
Share