Docozan

Docozan Uses, Dosage, Side Effects, Food Interaction and all others data.

Docozan exerts its antiviral effect on HSV by inhibiting fusion of the virus envelope with host cell plasma membranes, resulting in inhibition of viral entry into cells and subsequent viral replication.

Docozan is a saturated 22-carbon aliphatic alcohol which exhibits antiviral activity against many lipid enveloped viruses including herpes simplex virus (HSV). Docozan speeds the healing of cold sores and fever blisters on the face or lips. It also relieves the accompanying symptoms, including tingling, pain, burning, and itching. Docozan cannot, however, prevent cold sores or fever blisters from appearing.

Trade Name Docozan
Generic Docosanol
Docosanol Other Names 1-Docosanol, Behenic alcohol, Behenyl alcohol, Docosanol, Docosyl alcohol, N-Docosanol
Type
Formula C22H46O
Weight Average: 326.6
Monoisotopic: 326.354866094
Groups Approved, Investigational
Therapeutic Class Topical Antiviral preparations
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Docozan
Docozan

Uses

Docozan cream is used for the topical treatment of acute and recurrent oral-facial Herpes simplex episodes (Herpes labialis or cold sores or fever blisters).

Docozan is also used to associated treatment for these conditions: Cold Sore

How Docozan works

Docozan works by inhibiting fusion between the human cell plasma membrane and the herpes simplex virus (HSV) envelope, thereby preventing viral entry into cells and subsequent viral replication. Unlike other cold-sore antivirals, docosanol does not act directly on the virus, and as such it is unlikely it will produce drug resistant mutants of HSV.

Dosage

Docozan dosage

Adults and Children of 12 years of age and older: Apply 5 times a day until healed. Treatment should be begun at earliest signs or symptoms of herpes infection (Blisters, open sores, pain in the infected area, itching, burning, tingling or numbness).

Side Effects

Generally Docozan is well tolerated. Rarely burning, dryness of skin, itching, rash, swelling & headache are seen after administration of Docozan.

Toxicity

Symptoms of overdose include headache, abdominal pain, increased serum lipase, nausea, dyspepsia, dizziness, and hyperbilirubinemia.

Precaution

Cream should only be applied to lips and face. Avoid application in or near the eyes. Emphasize hand washing following application. Do not touch the lesion to prevent spread to others or to other parts of the body.

Herpes infection is a recurring disease. Viral reactivation may be triggered by ultraviolet radiation or sun exposure, stress, fatigue, chilling. Other possible triggers include fever, injury, menstruation, dental work and infectious diseases (cold, flu).

Patients are advised to notify health care professionals if lesions do not heal in 14 days or if fever, rash or swollen lymph nodes occur.

Food Interaction

No interactions found.

Elimination Route

Topical absorption has been shown to be minimal under conditions reflecting normal clinical use.

Pregnancy & Breastfeeding use

Pregnancy: There are no adequate and well-controlled studies in pregnant women. However, this medicine has not been shown to cause birth defects or other problems in animal studies using rats or rabbits.

Nursing Mothers: It is not known whether Docozan is excreted in breast milk. Because many drugs are excreted in breast milk, consideration should be given to discontinue nursing temporarily or withhold the drug while the mother is nursing.

Contraindication

Hypersensitivity to Docozan or any other components of the formulation.

Acute Overdose

No instance of accidental ingestion of Docozan has been reported. If ingested, gastric lavage and general supportive measures should be employed.

Innovators Monograph

You find simplified version here Docozan

Docozan contains Docosanol see full prescribing information from innovator Docozan Monograph, Docozan MSDS, Docozan FDA label

*** Taking medicines without doctor's advice can cause long-term problems.
Share