No-Burn Cream

No-Burn Cream Uses, Dosage, Side Effects, Food Interaction and all others data.

One of the short-acting sulfonamides used in combination with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections.

No-Burn Cream is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.

Trade Name No-Burn Cream
Availability Prescription only
Generic Sulfadiazine
Sulfadiazine Other Names 2-sulfanilamidopyrimidine, Sulfadiazin, Sulfadiazina, Sulfadiazine, Sulfadiazinum, Sulfapyrimidine, Sulphadiazine
Related Drugs azithromycin, clindamycin, sulfamethoxazole / trimethoprim, Bactrim, erythromycin, Zithromax, clarithromycin, Bactrim DS, penicillin v potassium, dapsone
Type
Formula C10H10N4O2S
Weight Average: 250.277
Monoisotopic: 250.052446274
Groups Approved, Investigational, Vet approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
No-Burn Cream
No-Burn Cream

Uses

No-Burn Cream is a sulfonamide antibiotic used in a variety of infections, such as urinary tract infections, trachoma, and chancroid.

For the treatment of rheumatic fever and meningococcal meningitis

No-Burn Cream is also used to associated treatment for these conditions: Chancroid, Chlamydial Infections, Conjunctivitis, Inclusion, Meningitis caused by Haemophilus influenzae, Meningococcal Meningitis, Nocardiosis, Plague, Plasmodium Infections, Toxoplasmosis, Trachoma, Urinary Tract Infection, Wound Infections, Bacterial otitis media caused by Haemophilus influenzae, Prophylaxis of Rheumatic fever, Recurrent Rheumatic fever

How No-Burn Cream works

No-Burn Cream is a competitive inhibitor of the bacterial enzyme dihydropteroate synthetase. This enzyme is needed for the proper processing of para-aminobenzoic acid (PABA) which is essential for folic acid synthesis. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.

Toxicity

Oral LD50 in mouse is 1500 mg/kg.

Food Interaction

No interactions found.

Elimination Route

No-Burn Cream is excreted largely in the urine.

Innovators Monograph

You find simplified version here No-Burn Cream

*** Taking medicines without doctor's advice can cause long-term problems.
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