No-Burn Cream
No-Burn Cream Uses, Dosage, Side Effects, Food Interaction and all others data.
One of the short-acting sulfonamides used in combination with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections.
No-Burn Cream is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
| Trade Name | No-Burn Cream |
| Availability | Prescription only |
| Generic | Sulfadiazine |
| Sulfadiazine Other Names | 2-sulfanilamidopyrimidine, Sulfadiazin, Sulfadiazina, Sulfadiazine, Sulfadiazinum, Sulfapyrimidine, Sulphadiazine |
| Related Drugs | azithromycin, clindamycin, sulfamethoxazole / trimethoprim, Bactrim, erythromycin, Zithromax, clarithromycin, Bactrim DS, penicillin v potassium, dapsone |
| Type | |
| Formula | C10H10N4O2S |
| Weight | Average: 250.277 Monoisotopic: 250.052446274 |
| Groups | Approved, Investigational, Vet approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
No-Burn Cream is a sulfonamide antibiotic used in a variety of infections, such as urinary tract infections, trachoma, and chancroid.
For the treatment of rheumatic fever and meningococcal meningitis
No-Burn Cream is also used to associated treatment for these conditions: Chancroid, Chlamydial Infections, Conjunctivitis, Inclusion, Meningitis caused by Haemophilus influenzae, Meningococcal Meningitis, Nocardiosis, Plague, Plasmodium Infections, Toxoplasmosis, Trachoma, Urinary Tract Infection, Wound Infections, Bacterial otitis media caused by Haemophilus influenzae, Prophylaxis of Rheumatic fever, Recurrent Rheumatic fever
How No-Burn Cream works
No-Burn Cream is a competitive inhibitor of the bacterial enzyme dihydropteroate synthetase. This enzyme is needed for the proper processing of para-aminobenzoic acid (PABA) which is essential for folic acid synthesis. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
Toxicity
Oral LD50 in mouse is 1500 mg/kg.
Food Interaction
No interactions found.No-Burn Cream Drug Interaction
Major: procaine penicillinModerate: pyrimethamineUnknown: aspirin, epinephrine, amoxicillin, RHO Immunoglobulin , azithromycin, multivitamin, ciprofloxacin, divalproex sodium, fluconazole, acetaminophen / butalbital / caffeine, ferrous sulfate, dextromethorphan / guaifenesin, acetaminophen, cobicistat / elvitegravir / emtricitabine / tenofovir, valproic acid, cyanocobalamin, ascorbic acid, phytonadione
No-Burn Cream Disease Interaction
Major: colitis, hematologic toxicity, hypersensitivity reactions, liver disease, porphyria, renal dysfunctionModerate: crystalluria, hemodialysis, urinary obstruction
Elimination Route
No-Burn Cream is excreted largely in the urine.
Innovators Monograph
You find simplified version here No-Burn Cream
