Toprano

Toprano Uses, Dosage, Side Effects, Food Interaction and all others data.

Toprano (chlortenoxicam) is a new nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic, anti-inflammatory and antipyretic properties. Toprano differs from other oxicam compounds in its potent inhibition of prostaglandin biosynthesis, a property that explains the particularly pronounced efficacy of the drug. Toprano is approved for use in Japan.

Toprano is a non-steroidal anti-inflammatory drug (NSAID) that belongs to the oxicam class. As with other NSAIDS, lornoxicam is a potent inhibitor of the cyclooxgenase enzymes, which are responsible for catalyzing the formation of prostaglandins (act as messenger molecules in the process of inflammation) and thromboxane from arachidonic acid. Unlike some NSAIDS, lornoxicam's inhibition of cyclooxygenase does not lead to an increase in leukotriene formation, meaning that arachidonic acid is not moved to the 5-lipoxygenase cascade, resulting in the minimization of the risk of adverse events.

Toprano
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Toprano
Generic	Lornoxicam
Lornoxicam Other Names	Chlortenoxicam, Lornoxicam, Lornoxicamum
Type
Formula	C₁₃H₁₀ClN₃O₄S₂
Weight	Average: 371.81 Monoisotopic: 370.9801259
Protein binding	Lornoxicam is 99% bound to plasma proteins (almost exlusively to serum albumin).
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Toprano is an NSAID indicated in the treatment of mild to moderate pain, as well as rheumatoid arthritis and osteoarthritis.

For the treatment of acute mild to moderate pain, as well as pain and inflammation of the joints caused by certain types of rheumatic diseases.

Toprano is also used to associated treatment for these conditions: Osteoarthritis (OA), Rheumatoid Arthritis, Acute mild to moderate pain

How Toprano works

Like other NSAIDS, lornoxicam's anti-inflammatory and analgesic activity is related to its inhibitory action on prostaglandin and thromboxane synthesis through the inhibition of both COX-1 and COX-2. This leads to the reduction of inflammation, pain, fever, and swelling, which are mediated by prostaglandins. However, the exact mechanism of lornoxicam, like that of the other NSAIDs, has not been fully determined.

Elimination Route

Toprano is absorbed rapidly and almost completely from the GI tract (90-100%).

Half Life

3-5 hours

Innovators Monograph

You find simplified version here Toprano

FAQ

What is Toprano used to treat?

Toprano is a non‐steroidal anti‐inflammatory drug (NSAID) that is used as a painkiller (analgesic). A high level of pain relief is experienced by about 45% of those with moderate to severe postoperative dental pain after a single dose of lornoxicam 8 mg, compared to about 10% with placebo.

How safe is Toprano?

Toprano is safe, effective and comparable to tramadol for relieving postoperative pain after operations on head and neck.

How does Toprano work?

Toprano anti-inflammatory and analgesic activity is related to its inhibitory action on prostaglandin and thromboxane synthesis through the inhibition of both COX-1 and COX-2.

What are the common side effects of Toprano?

Common side effects of Toprano are include:

Fever and chills
Skin rash
Increased blood pressure
Increased heartbeat
Nausea and Vomiting
Gastrointestinal Bleeding
Headache
Dizziness
Ringing or buzzing in the ears
Visual disturbances
Fluid Retention
Photosensitivity
Sleeplessness
Kidney Impairment
Stevens-Johnson Syndrome
Difficulty in breathing

Is Toprano safe during pregnancy?

Use of this medicine should be avoided if you are pregnant or planning a pregnancy in near future. Use of this medicine during the third trimester of pregnancy should be strictly avoided.

Is Toprano safe during breastfeeding?

Use of this Toprano should be avoided by nursing mothers as the risk of adverse effects on the infant is high.

Can I drink alcohol with Toprano?

Consumption of alcohol is not recommended during treatment with this medicine since it may increase the risk of severe adverse effects such as gastrointestinal bleeding, dizziness, drowsiness, etc.

Can I drive after taking Toprano?

Toprano may cause drowsiness or dizziness, do not drive a car or operate machinery while taking this medication.

How often can I take Toprano?

Pain 8-16 mg Toprano daily divided into 2 or 3 doses.

How long does Toprano take to work?

The effect of this medicine can be observed within 30 to 60 minutes of administration. The effect of this medicine lasts for an average duration of 24 hours.

How long does Toprano last?

The effect of this medicine can be observed within 30 to 60 minutes of administration. The effect of this medicine lasts for an average duration of 24 hours.

How long can I take Toprano?

Toprano 8-16 mg/day showed good safety and therapeutic activity in long term treatment. Clinical improvement was limited, but progression of the disease was controlled. No adverse events were complained.

Who should not take Toprano?

Toprano is contraindicated in patients who must not take other NSAIDs, possible reasons including salicylate sensitivity, gastrointestinal bleeding and bleeding disorders, and severe impairment of heart, liver or kidney function.

What happen If I missed dose of Toprano?

Take the missed dose as soon as you remember. If it is almost time for the next scheduled dose then the missed dose can be skipped.

Can I overdose on Toprano?

Contact your doctor if an overdose with this medicine is suspected. Symptoms of an overdose may include nausea, vomiting, dizziness, and disturbance in vision.

Is Toprano safe for kidney?

This Toprano is not recommended for use in patients having severe impairment of kidney function. Toprano should be administered with caution in patients with mild (serum creatinine 150-300 µmol/L) to moderate (serum creatinine 300-700 µmol/L) renal impairment due to dependency on renal prostaglandins for maintenance of renal blood flow (see section 4.2).