A-Gel
A-Gel Uses, Dosage, Side Effects, Food Interaction and all others data.
A-Gel is an ether of cellulose where some of the hydroxyl groups of the cellulose have been hydroxypropylated forming -OCH2CH(OH)CH3 groups. Lacrisertis a formulation of hydroxypropyl cellulose that is used for artificial tears. It is used to treat syndromes characterized by insufficient tear production (keratoconjunctivitis sicca), recurrent corneal erosions, decreased corneal sensitivity, exposure and neuroparalytic keratitis, and as a lubricant for artificial eyes. As a food additive, hydroxypropyl cellulose is used as a thickener and as an emulsion stabilizer.
A-Gel (cellulose, 2-hydroxypropyl ether) is a derivative of cellulose with both water solubility and organic solubility. A-Gel acts to stabilize and thicken the precorneal tear film and prolong the tear film breakup time which is usually accelerated in patients with dry eye states. A-Gel also acts to lubricate and protect the eye. A-Gel usually reduces the signs and symptoms resulting from moderate to severe dry eye syndromes, such as conjunctival hyperemia, corneal and conjunctival staining with rose bengal, exudation, itching, burning, foreign body sensation, smarting, photophobia, dryness and blurred or cloudy vision. Progressive visual deterioration which occurs in some patients may be retarded, halted, or sometimes reversed.
| Trade Name | A-Gel |
| Generic | Hydroxypropyl cellulose |
| Hydroxypropyl cellulose Other Names | Cellulose hydroxypropyl ether, Hiprolosa, Hydroxypropyl cellulose, Hydroxypropylcellulose, Hyprolose, Hyprolosum, Modified cellulose |
| Type | |
| Protein binding | None |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
A-Gel is a cellulose ether used to treat dry eyes.
Used to relieve dryness and irritation caused by reduced tear flow that occurs in certain eye diseases (keratoconjunctivitis sicca), recurrent corneal erosions, decreased corneal sensitivity, exposure and neuroparalytic keratitis, and as a lubricant for artificial eyes.
A-Gel is also used to associated treatment for these conditions: Corneal Erosions, Corneal Inflammation, Dry Eye Syndrome (DES), Keratoconjunctivitis Sicca
How A-Gel works
A-Gel is a derivative of cellulose that is soluble in both water and organic solvents. It is particularly good at trapping water and producing a film that serves as a barrier to water loss. A-Gel possesses good surface activity but does not gel as it forms open helical coils. In general A-Gel is a water-soluble thickener, emulsifier and film-former often used in tablet coating.
Toxicity
LD50=10200 mg/kg (oral, rat)
Food Interaction
No interactions found.Elimination Route
Studies conducted in rats fed 14 C-labeled hydroxypropyl cellulose demonstrated that when orally administered, hydroxypropyl cellulose is not absorbed from the gastrointestinal tract and is quantitatively excreted in the feces.
Elimination Route
Studies conducted in rats fed 14C-labeled hydroxypropyl cellulose demonstrated that when orally administered, hydroxypropyl cellulose is not absorbed from the gastrointestinal tract and is quantitatively excreted in the feces.
Innovators Monograph
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