ABC294640
ABC294640 Uses, Dosage, Side Effects, Food Interaction and all others data.
ABC294640, also known as ABC294640, is a selective sphingosine kinase-2 (SK2) inhibitor that is orally administered. This drug has potential anticancer, anti-inflammatory, and antiviral activities, with potential applications in oncology, inflammation, the gastrointestinal system, and COVID-19.
| Trade Name | ABC294640 |
| Generic | Opaganib |
| Opaganib Other Names | ABC-294640, ABC294640, Opaganib, Yeliva |
| Type | |
| Formula | C23H25ClN2O |
| Weight | Average: 380.92 Monoisotopic: 380.1655411 |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
How ABC294640 works
ABC294640 selectively inhibits sphingosine kinase-2 (SK2). This inhibition blocks the synthesis of sphingosine 1-phosphate (S1P) and its activities (which includes regulation of fundamental biological processes such as cell proliferation, migration, immune cell trafficking, angiogenesis, immune-modulation, and suppression of innate immune responses from T-cells). This drug has dual anti-inflammatory and antiviral activity targeting a host cell component and is unaffected by viral mutation, contributing to minimization of the likelihood of resistance. It is currently being investigated against COVID-19 as it has demonstrated anti-SARS-CoV-2 activity in studies.
Innovators Monograph
You find simplified version here ABC294640
