Acemox Tablet 250 mg

Acemox Tablet 250 mg Uses, Dosage, Side Effects, Food Interaction and all others data.

Acemox Tablet 250 mg is a carbonic anhydrase inhibitor. This enzyme catalyzes the reversible reaction involving the hydration of carbon-di-oxide and the dehydration of carbonic acid. In the eye, this inhibitory action of Acemox Tablet 250 mg decreases the secretion of aqueous humor and results in a drop in intraocular pressure, a reaction considered desirable in case of glaucoma. Inhibition of carbonic anhydrase in the central nervous system appears to retard abnormal paroxysmal and excessive discharge from central nervous system neurons. So, Acemox Tablet 250 mg is also used as an adjuvant in the treatment of epilepsy.

Acemox Tablet 250 mg is a potent carbonic anhydrase inhibitor, effective in the control of fluid secretion, in the treatment of certain convulsive disorders and in the promotion of diuresis in instances of abnormal fluid retention. Acemox Tablet 250 mg is not a mercurial diuretic. Rather, it is a nonbacteriostatic sulfonamide possessing a chemical structure and pharmacological activity distinctly different from the bacteriostatic sulfonamides.

Acemox Tablet 250 mg
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Acemox Tablet 250 mg
Availability	Prescription only
Generic	Acetazolamide
Acetazolamide Other Names	Acetazolamid, Acetazolamida, Acétazolamide, Acetazolamide, Acetazolamidum
Related Drugs	gabapentin, furosemide, hydrochlorothiazide, clonazepam, spironolactone, lamotrigine, diazepam, pregabalin, Lyrica, topiramate
Weight	250 mg
Type	Tablet
Formula	C₄H₆N₄O₃S₂
Weight	Average: 222.245 Monoisotopic: 221.988131458
Protein binding	98%
Groups	Approved, Vet approved
Therapeutic Class	Carbonic anhydrase inhibitor
Manufacturer	ACME Laboratories Ltd.
Available Country	Bangladesh
Last Updated:	October 19, 2023 at 6:27 am

Uses

Open angle glaucoma, secondary glaucoma and as an adjuvant in the treatment of edema and epilepsy.

Acemox Tablet 250 mg is also used to associated treatment for these conditions: Edema, Familial periodic paralysis, Grand mal Generalized tonic-clonic seizure, Metabolic Alkalosis, Open Angle Glaucoma (OAG), Other and unspecified effects of high altitude, Acute Angle closure glaucoma, Cystine renal calculi, Drug-induced edema, Nonuveitic secondary glaucoma, Salicylate intoxication, Urine alkalinization therapy

How Acemox Tablet 250 mg works

The anticonvulsant activity of Acemox Tablet 250 mg may depend on a direct inhibition of carbonic anhydrase in the CNS, which decreases carbon dioxide tension in the pulmonary alveoli, thus increasing arterial oxygen tension. The diuretic effect depends on the inhibition of carbonic anhydrase, causing a reduction in the availability of hydrogen ions for active transport in the renal tubule lumen. This leads to alkaline urine and an increase in the excretion of bicarbonate, sodium, potassium, and water.

Dosage

Acemox Tablet 250 mg dosage

Adults : Initially 250 mg (1 tablet) 4 times daily. Dose should be adjusted later with individual need.

Children : ½ to 2 tablets in divided doses.

In intraocular pressure: 1 tablet 6 hourly. In acute condition, dose should be started with 2 tablets followed by 1 tablet 6 hourly or as directed by the physician

Side Effects

Headache, drowsiness, dizziness, fatigue, anorexia, polyurea, insomnia, gastrointestinal upset.

Food Interaction

Drink plenty of fluids.
Take with food. Take at least 6 hours before bedtime.

Acemox Tablet 250 mg Drug Interaction

Major: topiramate, topiramateModerate: duloxetine, duloxetineUnknown: diphenhydramine, diphenhydramine, omega-3 polyunsaturated fatty acids, omega-3 polyunsaturated fatty acids, pregabalin, pregabalin, cyanocobalamin, cyanocobalamin, ascorbic acid, ascorbic acid, cholecalciferol, cholecalciferol, ondansetron, ondansetron, cetirizine, cetirizine

Acemox Tablet 250 mg Disease Interaction

Major: bone marrow depression/blood dyscrasias, adrenal insufficiency, closed-angle glaucoma, hypokalemia, hyponatremia, severe kidney disease, severe liver diseaseModerate: respiratory acidosis, renal dysfunction, diabetes mellitus, gout, metabolic acidosis

Half Life

3 to 9 hours

Pregnancy & Breastfeeding use

There are no adequate and well controlled studies in pregnant women and neonates. So, Acemox Tablet 250 mg should be used with care in those physiological conditions.

Contraindication

Acemox Tablet 250 mg is contraindicated in cases of marked kidney and liver diseases or dysfunction, in situations in which sodium and or potassium blood serum levels decreased. Acemox Tablet 250 mg is also contraindicated in patients with chronic noncongestive angle closure glaucoma