Acetazine

Acetazine Uses, Dosage, Side Effects, Food Interaction and all others data.

Acetazine is one of the phenothiazine derivative psychotropic drugs, used little in humans, however frequently in animals as a sedative and antiemetic.

Acetazine is one of the phenothiazine derivative psychotropic drugs. Acetazine has actions at all levels of the central nervous system-primarily at subcortical levels-as well as on multiple organ systems. Acetazine has strong antiadrenergic and weaker peripheral anticholinergic activity; ganglionic blocking action is relatively slight. It also possesses slight antihistaminic and antiserotonin activity.

Trade Name Acetazine
Generic Acepromazine
Acepromazine Other Names Acepromazina, Acepromazine, Acepromazinum, Acetazine, Acetopromazine, Acetylpromazine
Type
Formula C19H22N2OS
Weight Average: 326.456
Monoisotopic: 326.145284026
Groups Experimental, Vet approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Acetazine
Acetazine

Uses

Acetazine was first used in humans in the 1950s as an antipsychotic agent. It is now rarely used in humans. Acetazine is frequently used in animals as a sedative and antiemetic. Its principal value is in quietening and calming anxious animals.

How Acetazine works

Acetazine acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side-effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism - controversial) and finally on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side-effects).

Toxicity

Agitation, coma, convulsions, difficulty breathing, difficulty swallowing, dry mouth, extreme sleepiness, fever, intestinal blockage, irregular heart rate, low blood pressure, restlessness

Food Interaction

  • Avoid alcohol.
  • Take with food. Food reduces irritation.

Half Life

3 hours in horses.

Innovators Monograph

You find simplified version here Acetazine

http://classyfire.wishartlab.com/tax_nodes/C0000000
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http://classyfire.wishartlab.com/tax_nodes/C0000119
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http://classyfire.wishartlab.com/tax_nodes/C0001349
http://classyfire.wishartlab.com/tax_nodes/C0002239
http://classyfire.wishartlab.com/tax_nodes/C0004139
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0003940
http://classyfire.wishartlab.com/tax_nodes/C0004150
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:44932
http://www.hmdb.ca/metabolites/HMDB0015552
http://www.genome.jp/dbget-bin/www_bget?drug:D07065
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=6077
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508205
https://www.chemspider.com/Chemical-Structure.5852.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50131719
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=155
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=44932
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL39560
https://zinc.docking.org/substances/ZINC000000057198
http://www.pharmgkb.org/drug/PA164783999
https://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/PMZ
https://en.wikipedia.org/wiki/Acepromazine
*** Taking medicines without doctor's advice can cause long-term problems.
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