Acetazine
Acetazine Uses, Dosage, Side Effects, Food Interaction and all others data.
Acetazine is one of the phenothiazine derivative psychotropic drugs, used little in humans, however frequently in animals as a sedative and antiemetic.
Acetazine is one of the phenothiazine derivative psychotropic drugs. Acetazine has actions at all levels of the central nervous system-primarily at subcortical levels-as well as on multiple organ systems. Acetazine has strong antiadrenergic and weaker peripheral anticholinergic activity; ganglionic blocking action is relatively slight. It also possesses slight antihistaminic and antiserotonin activity.
| Trade Name | Acetazine |
| Generic | Acepromazine |
| Acepromazine Other Names | Acepromazina, Acepromazine, Acepromazinum, Acetazine, Acetopromazine, Acetylpromazine |
| Type | |
| Formula | C19H22N2OS |
| Weight | Average: 326.456 Monoisotopic: 326.145284026 |
| Groups | Experimental, Vet approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Acetazine was first used in humans in the 1950s as an antipsychotic agent. It is now rarely used in humans. Acetazine is frequently used in animals as a sedative and antiemetic. Its principal value is in quietening and calming anxious animals.
How Acetazine works
Acetazine acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side-effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism - controversial) and finally on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side-effects).
Toxicity
Agitation, coma, convulsions, difficulty breathing, difficulty swallowing, dry mouth, extreme sleepiness, fever, intestinal blockage, irregular heart rate, low blood pressure, restlessness
Food Interaction
- Avoid alcohol.
- Take with food. Food reduces irritation.
Half Life
3 hours in horses.
Innovators Monograph
You find simplified version here Acetazine
