Acical-C 1000 mg+327 mg+500 mg Effervescent Tablet

Acical-C 1000 mg+327 mg+500 mg Effervescent Tablet Uses, Dosage, Side Effects, Food Interaction and all others data.

Calcium carbonate reacts with gastric acid to produce a salt and water. For calcium carbonate the postulated chemical reaction is:

CaCO3 + 2HCl = CaCl2 + H2O + CO2

Indicated in raised calcium requirement e.g. during pregnancy and lactation, and in children and adolescents at time of rapid growth, inadequate intake of calcium in the diet due to malnutrition, prevention and treatment of osteoporosis, disorders of osteogenesis and tooth formation, latent tetany.

Gastric-peptic disease occurs as a result of an imbalance between protective factors, such as mucus, bicarbonate, and prostaglandin secretion, and aggressive factors, such as hydrochloric acid, pepsin, and Helicobacter pylori (H. pylori). Antacids work by restoring acid-base balance, attenuating the pepsin activity and increasing bicarbonate and prostaglandin secretion. The acid-neutralizing capacity of calcium carbonate is 58 mEq/15 ml.When used as a nutritional supplement, calcium carbonate acts by directly increasing calcium stores within the body.

Acical-C 1000 mg+327 mg+500 mg Effervescent Tablet
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Acical-C 1000 mg+327 mg+500 mg Effervescent Tablet
Generic	Calcium Lactate Gluconate + Calcium Carbonate + Vitamin C
Weight	1000 mg+327 mg+500 mg
Type	Effervescent Tablet
Therapeutic Class	Specific mineral & vitamin combined preparations
Manufacturer	ACI Limited
Available Country	Bangladesh
Last Updated:	September 24, 2024 at 5:38 am

Acical-C 1000 mg+327 mg+500 mg Effervescent Tablet

Uses

This is indicated in- Increased demand for Calcium and Vitamin-C, e.g. pregnancy, lactation, periods of rapid growth (childhood, adolescence), in old age During infectious disease and convalescence Treatment of calcium and vitamin-C deficiency Osteoporosis Premenstrual syndrome Postmenopausal problems Adjuvant in colds and influenza

Acical-C 1000 mg+327 mg+500 mg Effervescent Tablet is also used to associated treatment for these conditions: Acid Reflux, Acid indigestion, Bloating, Calcium Deficiency, Calcium Metabolism Disorders, Calcium and Vitamin D Deficiencies, Colic, Dyspepsia, Gastric Ulcer, Gastroesophageal Reflux, Heartburn, Hemorrhoids, Hot Flushes, Hyperacidity, Hyperphosphataemia, Hypovitaminosis D, Low Bone Density, Osteodystrophy, Osteomalacia, Osteoporosis, Postmenopausal Osteoporosis, Postoperative Gas, Proctitis, Vertebral Fractures, Calcium loss, Gastrointestinal ulceration, Dietary supplementationCalcium Deficiency, Hypovitaminosis D, Osteomalacia, Osteoporosis, Calcium supplementation

How Acical-C 1000 mg+327 mg+500 mg Effervescent Tablet works

Calcium carbonate is a basic inorganic salt that acts by neutralizing hydrochloric acid in gastric secretions. It also inhibits the action of pepsin by increasing the pH and via adsorption. Cytoprotective effects may occur through increases in bicarbonate ion (HCO₃^-) and prostaglandins. Neutralization of hydrochloric acid results in the formation of calcium chloride, carbon dioxide and water. Approximately 90% of calcium chloride is converted to insoluble calcium salts (e.g. calcium carbonate and calcium phosphate).

Dosage

Acical-C 1000 mg+327 mg+500 mg Effervescent Tablet dosage

Children 3 to 7 years: ½ effervescent tablet daily.Adults & children above 7 years: 1 effervescent tablet daily. Dissolve 1 tablet in a glass of water before consumption.

Side Effects

In rare cases, mild gastrointestinal disturbances (bloating, diarrhea) can occur. In predisposed patients, prolonged treatment with high doses may promote the formation of calculi in the urinary tract.

Precaution

For patients with mild hypercalciuria (exceeding 300 mg = 7.5 mmol/24 hours), with mild or moderate impairment of renal function or with a history of urinary concrements, monitoring of calcium excretion in the urine is required. If necessary, the dosage should be reduced or therapy should be discontinued. High doses of vitamin-D and derivatives should be avoided during treatment with this preparation unless especially indicated.Since citrate salts have been reported to increase aluminium absorption, this medicine should be used with caution in patients with severely impaired renal function, especially those receiving aluminium-containing preparations. The sugar content should be taken into account by diabetic patients.

Interaction

Potentially hazardous interactions: Digoxin, tetracycline, furosemide, pentagastrin. Aminophylline, bleomycin, erythromycin, lactobionate, nafcillin, nitrofurantion, conjugated estrogens, salfafurazole, diethanolamine, chloramphenicol. Potentially useful interactions: Vitamin-D, oxytocin and prostaglandins Vitamin-C enhances iron absorption

Volume of Distribution

Calcium is rapidly distributed taken up by skeletal tissues following absorption and distribution into extracellular fluids. Bone contains 99% of the body's calcium and the remaining 1% is approximately equally distributed between intracellular and extracellular fluids.

Elimination Route

Maximal absorption occurs at doses of 500 mg or less taken with food. Oral bioavailability depends on intestinal pH, the presence of food and dosage.

Elimination Route

Excreted mainly in the feces. The majority of renally filtered calcium is reabsorbed in the ascending limb of the loop of Henle and the proximal and distal convoluted tubules. Also secreted by sweat glands.

Pregnancy & Breastfeeding use

Epidemiological studies with oral calcium have shown no increase in the teratogenic hazard to the fetus. Although supplemental calcium may be excreted in breast milk, the concentration is unlikely to be sufficient to produce any adverse effect on the neonate. Vitamin C may be taken safely during pregnancy and lactation.

Contraindication

Hypercalcemia (e.g. in hyperparathyroidism, vitamin-D overdosage, decalcifying tumors such as plasmocytoma, bone metastases); severe hypercalciuria; severe renal failure.Patients with hyperoxalauria, glucose-6- phosphate dehydrogenase deficiency, or iron overload. Larger doses may lead to gastrointestinal tract upset.

Special Warning

USE IN CHILDREN: Calcium carbonate has been extensively studied in children and infants with chronic renal failure and is both safe and effective.

USE IN ELDERLY: In case of elderly patients with renal failure when calcium carbonate is taken constipation may be troublesome one for this group. For this reason, monitoring of serum calcium and phosphate is of course indicated for elderly patients.

Acute Overdose

Acute overdosage has not been reported. It would be expected to cause gastrointestinal disturbances but not to result in hypercalcemia, except in patients treated with a very high dosage of vitamin-D and derivatives.