Acmecilin Injection 250 mg/vial

Acmecilin Injection 250 mg/vial Uses, Dosage, Side Effects, Food Interaction and all others data.

Acmecilin Injection 250 mg/vial
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Acmecilin Injection 250 mg/vial
Generic	Ampicillin Sodium
Weight	250 mg/vial
Type	Injection
Therapeutic Class
Manufacturer	ACME Laboratories Ltd.
Available Country	Bangladesh
Last Updated:	October 19, 2023 at 6:27 am

Uses

Ampicillin is indicated in the treatment of infections caused by susceptible strains of the designated organism listed below: Infections of the Genitourinary Tract Including Gonorrhea: E. coli, P. mirabilis, enterococci, Shigella, S. typhosa and other Salmonella, and nonpenicillinase-producing N. gononhoeae. ... Read more

Dosage

Acmecilin Injection 250 mg/vial dosage

Intra-articular:Supplement in systemic therapy for treatment of susceptible infections- Adult:500 mg daily. Child:<10 yrHalf of adult routine dosage. Intraperitoneal:Supplement in systemic therapy for treatment of susceptible infections- Adult:500 mg daily. Child:<10 yrHalf of adult routine dosage. Intrapleural:Supplement in systemic therapy for treatment of susceptible infections- Adult:500 mg daily. Child:<10 yrHalf of adult routine dosage Intravenous:Meningitis- Adult:2 gm 6 hrly. Child:150 mg/kg daily in divided doses. Intrapartum prophylaxis against group B Streptoccocal infection in neonates- Adult:Initially, 2 gm via IV inj followed by 1 gm 4 hrly until delivery. Oral:Biliary tract infections, Bronchitis, Endocarditis, Gastroenteritis, Listeriosis, Otitis media, Perinatal streptococcal infections, Peritonitis- Adult:0.25-1 gm 6 hrly. Child:<10 yrHalf of adult routine dosage. Typhoid and paratyphoid fever- Adult:1-2 gm 6 hrly for 2 wk in acute infections, and 4-12 wk in carriers. Uncomplicated gonorrhoea- Adult:2 gm with 1 gm of probenecid as single dose, recommended to be repeated in female patients. Urinary tract infections- Adult:500 mg 8 hrly. Parenteral:Susceptible infections- Adult:500 mg 6 hrly, via IM or slow IV inj over 3-5 min or by infusion. Child:<10 yrHalf of adult routine dosage. Septicaemia- Adult:150-200 mg/kg daily. Initiate with IV admin for at least 3 days, then continue with IM inj 3-4 hrly. Continue treatment for at least 48-72 hr after the patient has become asymptomatic or when there is evidence of bacterial eradication. Recommended treatment duration for infections caused by group-A β-haemolytic streptococci: At least 10-days, to prevent occurrence of acute rheumatic fever or acute glomerulonephritis. Child:Same as adult dose. Should be taken on an empty stomach. Take 1 hr before or 2 hr after meals.

Side Effects

Nausea, vomiting, diarrhoea, erythematous maculo-papular rashes, sore mouth, black/hairy tongue, rash, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, angioedema, fever, joint pains, serum sickness-like symptoms, haemolytic anaemia, thrombocytopenia, leucopenia, neutropenia, coagulation disorders, prolonged bleeding time and prothrombin time, CNS toxicity (e.g. convulsions); paraesthesia, nephropathy, interstitial nephritis, hepatitis, cholestatic jaundice, moderate and transient increase in transaminases, Anaphylaxis, Clostridium difficile-associated diarrhoea (CDAD).

Precaution

Patient with history of β-lactam allergy. During renal impairment, Pregnancy and lactation.

Interaction

May reduce the efficacy of oral contraceptives. May alter INR while on warfarin and phenindione. May reduce the efficacy of oral typhoid vaccines. May reduce the excretion of methotrexate. Reduced excretion with probenecid and sulfinpyrazone, resulting to increased risk of toxicity. Allopurinol increases ampicillin-induced skin reactions. Reduced absorption with chloroquine. Bacteriostatic antibacterials (e.g. erythromycin, chloramphenicol, tetracycline) may interfere with the bactericidal action of ampicillin.

Pregnancy & Breastfeeding use

Pregnancy Category B. Either animal-reproduction studies have not demonstrated a fetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).