Activon Arthritis

Activon Arthritis Uses, Dosage, Side Effects, Food Interaction and all others data.

A depressor amine derived by enzymatic decarboxylation of histidine. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.

Activon Arthritis stimulates gastric gland secretion, causing an increased secretion of gastric juice of high acidity. This action is probably due mainly to a direct action on parietal and chief gland cells.

Trade Name Activon Arthritis
Generic Histamine
Histamine Other Names 4-imidazoleethylamine, 5-imidazoleethylamine, beta-aminoethylglyoxaline, beta-aminoethylimidazole
Type
Formula C5H9N3
Weight Average: 111.1451
Monoisotopic: 111.079647303
Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Activon Arthritis
Activon Arthritis

Uses

Activon Arthritis is an ingredient of topical drugs for the relief of joint pain or muscle aches and pains.

Activon Arthritis phosphate is indicated as a diagnostic aid for the evaluation of gastric acid secretory function.

Activon Arthritis is also used to associated treatment for these conditions: Migraine

How Activon Arthritis works

Activon Arthritis acts directly on the blood vessels to dilate arteries and capillaries; this action is mediated by both H 1- and H 2-receptors. Capillary dilatation may produce flushing of the face, a decrease in systemic blood pressure, and gastric gland secretion, causing an increased secretion of gastric juice of high acidity. Increased capillary permeability accompanies capillary dilatation, producing an outward passage of plasma protein and fluid into the extracellular spaces, an increase in lymph flow and protein content, and the formation of edema. In addition, histamine has a direct stimulant action on smooth muscle, producing contraction if H 1-receptors are activated, or mostly relaxation if H 2-receptors are activated. Also in humans, the stimulant effect of histamine may cause contraction of the intestinal muscle. However, little effect is noticed on the uterus, bladder, or gallbladder. Activon Arthritis has some stimulant effect on duodenal, salivary, pancreatic, bronchial, and lacrimal glands. Activon Arthritis also can bind to H3 and H4 receptors which are involved in the CNS/PNS neurotransmitter release and immune system chemotaxis, respectively.

Toxicity

LD50=807 mg/kg (mouse, oral). Side effects can lead to hypertension, hypotension, headache, dizziness, nervousness and tachycardia. Large overdoses can lead to seizures.

Food Interaction

No interactions found.

Elimination Route

Readily absorbed after parenteral administration.

Innovators Monograph

You find simplified version here Activon Arthritis

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0004707
http://classyfire.wishartlab.com/tax_nodes/C0000278
http://classyfire.wishartlab.com/tax_nodes/C0002449
http://classyfire.wishartlab.com/tax_nodes/C0004253
http://classyfire.wishartlab.com/tax_nodes/C0003899
http://classyfire.wishartlab.com/tax_nodes/C0000078
http://classyfire.wishartlab.com/tax_nodes/C0004144
http://classyfire.wishartlab.com/tax_nodes/C0004139
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0000469
http://classyfire.wishartlab.com/tax_nodes/C0004150
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:18295
http://www.genome.jp/dbget-bin/www_bget?cpd:C00388
http://www.hmdb.ca/metabolites/HMDB0060263
http://www.genome.jp/dbget-bin/www_bget?drug:D08040
http://www.genome.jp/dbget-bin/www_bget?cpd:C00388
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=774
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=175426988
https://www.chemspider.com/Chemical-Structure.753.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50121205
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=5333
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=18295
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL90
https://zinc.docking.org/substances/ZINC000000388081
http://www.pharmgkb.org/drug/PA449880
https://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/HSM
https://www.drugs.com/cons/histamine-phosphate-intradermal.html
https://en.wikipedia.org/wiki/Histamine
*** Taking medicines without doctor's advice can cause long-term problems.
Share