Actonel Wekelijks

Actonel Wekelijks Uses, Dosage, Side Effects, Food Interaction and all others data.

Actonel Wekelijks is a third generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease. It functions by preventing resorption of bone.

Risedronate is a pyridine-based bisphosphonate that inhibits bone resorption caused by osteoclasts.

Trade Name Actonel Wekelijks
Generic Risedronic acid
Risedronic acid Other Names Acide risédroniqe, Acido risedronico, Acidum risedronicum, Risedronate, Risedronic acid, Risedronsäure
Type
Formula C7H11NO7P2
Weight Average: 283.1123
Monoisotopic: 283.001074735
Protein binding

~24%.

Groups Approved, Investigational
Therapeutic Class
Manufacturer Euro Registratie Collectief
Available Country Netherlands
Last Updated: September 19, 2023 at 7:00 am
Actonel Wekelijks
Actonel Wekelijks

Uses

Actonel Wekelijks is a bisphosphonate used to treat osteoporosis and Paget's disease.

Actonel Wekelijks is indicated for the treatment of osteoperosis in men, treatment of Paget's disease, treatment and prevention of osteoperosis in postmenopausal women, and treatment and prevention of glucocorticoid-induced osteoperosis.

Actonel Wekelijks is also used to associated treatment for these conditions: Hypercalcemia of Malignancy, Osteoporosis, Paget’s Disease

How Actonel Wekelijks works

Risedronatic acid binds to bone hydroxyapatite. Bone resorption causes local acidification, releasing risedronic acid which is that taken into osteoclasts by fluid-phase endocytosis. Endocytic vesicles are acidified, releasing risedronic acid to the cytosol of osteoclasts where they induce apoptosis through inhbition of farnesyl pyrophosphate synthase. Inhibition of osteoclasts results in decreased bone resorption.

Toxicity

In clinical trials, over 10% of patients experienced back pain, arthralgia, abdominal pain, and dyspepsia. Less commonly, patients experience angioedema, generalized rash, bullous skin reactions, iritis, and uveitis.

Patients experiencing an overdose may experience a decrease in serum calcium and phosphorus. Patients can be given milk or antacids to bind the drug and reduce its absorption. In more severe cases, patients may require gastric lavage and intravenous calcium. A lethal dose in rats is equivalent to 320 to 620 times the human dose based on surface area.

Food Interaction

  • Administer vitamin supplements. Patients may require supplemental vitamin D.
  • Avoid multivalent ions. Calcium, antacids, and divalent ions may interfere with the absorption of this medication.
  • Take on an empty stomach.
  • Take with a full glass of water.

Volume of Distribution

13.8 L/kg.

Elimination Route

Oral bioavailability is 0.63% and maximum absorption is approximately 1 hour after dosing. Administration half and hour before a meal reduces bioavailability by 55% compared to fasting and dosing 1 hour before a meal reduces bioavailability by 30%.

Half Life

The initial half life of risedronic acid is approximately 1.5 hours, with a terminal half life of 561 hours.

Clearance

Mean renal clearance was 52mL/min and mean total clearance was 73mL/min.

Elimination Route

Risedronate is excreted by the kidneys and the unabsorbed dose is eliminated in the feces.

Innovators Monograph

You find simplified version here Actonel Wekelijks

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0000264
http://classyfire.wishartlab.com/tax_nodes/C0000419
http://classyfire.wishartlab.com/tax_nodes/C0000327
http://classyfire.wishartlab.com/tax_nodes/C0000327
http://classyfire.wishartlab.com/tax_nodes/C0000089
http://classyfire.wishartlab.com/tax_nodes/C0001302
http://classyfire.wishartlab.com/tax_nodes/C0004144
http://classyfire.wishartlab.com/tax_nodes/C0004139
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0000400
http://classyfire.wishartlab.com/tax_nodes/C0000323
http://classyfire.wishartlab.com/tax_nodes/C0000278
http://classyfire.wishartlab.com/tax_nodes/C0003940
http://classyfire.wishartlab.com/tax_nodes/C0004150
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:8869
http://www.hmdb.ca/metabolites/HMDB0015022
http://www.genome.jp/dbget-bin/www_bget?drug:D08484
http://www.genome.jp/dbget-bin/www_bget?cpd:C08233
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5245
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507526
https://www.chemspider.com/Chemical-Structure.5055.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12576
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=55685
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=8869
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL923
https://zinc.docking.org/substances/ZINC000001531009
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP000658
http://www.pharmgkb.org/drug/PA451255
https://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/RIS
http://www.rxlist.com/cgi/generic/risedronate.htm
https://www.drugs.com/cdi/risedronate-tablets.html
http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/act1580.shtml
https://en.wikipedia.org/wiki/Risedronic_acid
*** Taking medicines without doctor's advice can cause long-term problems.
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