Adco-Cefotaxime

Adco-Cefotaxime Uses, Dosage, Side Effects, Food Interaction and all others data.

Adco-Cefotaxime is indicated in the treatment of the following serious infections-

Respiratory Tract Infections: Due to S. pneumoniae, Klebsiella, H. influenzae, S. aureus and group A beta-hemolytic streptococci. Adco-Cefotaxime is effective in the eradication of streptococci from the nasopharynx.

Urinary Tract Infections: Due to E. coli, P. mirabilis, Klebsiella species, and some strains of enterobacter and enterococci .

Skin and Skin Structure Infections: Due to S. aureus, group A beta-hemolytic streptococci, and other strains of streptococci .

Biliary Tract Infections: Due to E. coli, various strains of streptococci, P. mirabilis, Klebsiella species and S. aureus .

Bone and Joint Infections: Due to S. aureus.

Genital Infections: Due to E . coli, P . mirabilis, Klebsiella species, and some strains of enterococci .

Septicemia: Due to S. pneumoniae, S. aureus, P. mirabilis, E. coli, and Klebsiella species .

Trade Name Adco-Cefotaxime
Availability Prescription only
Generic Cefazolin
Cefazolin Other Names Cefamezin, Cefazolin, Cefazolina, Cefazoline, Cefazolinum, Cephamezine, Cephazolidin, Cephazolin, Cephazoline
Related Drugs amoxicillin, doxycycline, ciprofloxacin, cephalexin, metronidazole, azithromycin, clindamycin, ceftriaxone, levofloxacin, Augmentin
Type
Formula C14H14N8O4S3
Weight Average: 454.507
Monoisotopic: 454.030013046
Protein binding

74-86%

Groups Approved
Therapeutic Class  
Manufacturer
Available Country South Africa
Last Updated: September 19, 2023 at 7:00 am
Adco-Cefotaxime
Adco-Cefotaxime

How Adco-Cefotaxime works

In vitro tests demonstrate that the bactericidal action of cephalosporins results from inhibition of cell wall synthesis. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins.

Dosage

Adco-Cefotaxime dosage

Usual Adult Dosage

• For moderate to severe infection dose is 500 mg to 1 gm and frequency is every 6 to 8 hours

• For mild infections caused by Gram positive cocci dose is 250 mg to m00 mg and frequency is every 8 hours

• For acute uncomplicated urinary tract infection dose is 1 gm and frequency is every 12 hours

• For pneumococcal pneumonia dose is 500 gm and frequency is every 12 hours

• For severe life threatening infections dose is 1 gm to 1.5 gm and frequency is every 6 hours

Perioperative Prophylactic dose: To prevent postoperative infection, the recommended doses are: I. 1 gm IV or IM administered 1/2 hour to 1 hour prior to the start of surgery II . For lengthy surgery (e.g. 2 hours or more), 500 mg to 1 gm IV or IM during surgery III. 500 mg to 1 gm IV or IM every 6 to 8 hours for 24 hours postoperatively

Intramuscular Administration: Reconstitute vials with sterile Water for Injection. Shake well until dissolved. Adco-Cefotaxime should be injected into a large muscle mass

Intravenous Administration: For direct injection reconstitution, dilute vials with approximately 10 ml Sterile Water for Injection for 500 mg and 1 gm. Inject the solution slowly over 3 to 5 minutes. For continuous infusion dilute reconstituted in 50 to 100 mL of one of the following solutions: 0.9% Sodium Chloride Injection,5% or 10% Dextrose Injection, 5% Dextrose and 0 .9% Sodium Chloride Injection.

Pediatric Dosage: In pediatric patients, a total daily dosage of 25 to 50 mg per kg of body weight, divided into 3 or 4 equal doses, is effective for most mild to moderately severe infections. Total daily dosage may be increased to 100 mg per kg of body weight for severe infections. Since safety of Adco-Cefotaxime use in infants has not been established, it is not recommended

Side Effects

Swelling, redness, pain, or soreness at the injection site may occur. This medication may also rarely cause loss of appetite, nausea, vomiting, diarrhea or headache

Precaution

When Adco-Cefotaxime is administered to patients with impaired renal function, a lower daily dosage is required or otherwise, seizures may occur. it should be prescribed with caution in individuals with a history of gastrointestinal disease, particularly colitis.

Food Interaction

No interactions found.

Adco-Cefotaxime Hypertension interaction

[Moderate] Parenteral cefazolin sodium contains approximately 46 mg (2 mEq) of sodium per each gram of cefazolin activity.

The sodium content should be considered in patients with conditions that may require sodium restriction, such as congestive heart failure, hypertension, and fluid retention.

Elimination Route

Not absorbed from GI tract. Must be administered parenterally. Peak serum concentrations attained 1-2 hours post intramuscular injection.

Half Life

The serum half-life is approximately 1.8 hours following IV administration and approximately 2.0 hours following IM administration.

Elimination Route

Adco-Cefotaxime is present in very low concentrations in the milk of nursing mothers. Adco-Cefotaxime is excreted unchanged in the urine. In the first six hours approximately 60% of the drug is excreted in the urine and this increases to 70%-80% within 24 hours.

Pregnancy & Breastfeeding use

There are no adequate studies in pregnant women for this drug so this drug should be used during pregnancy only if clearly needed. Adco-Cefotaxime is present in very low concentrations in the milk of nursing mothers so caution should be exercised.

Interaction with other Medicine

Probenecid may decrease renal tubular secretion of Adco-Cefotaxime, when used concurrently, resulting in increased Adco-Cefotaxime blood levels

Innovators Monograph

You find simplified version here Adco-Cefotaxime

Adco-Cefotaxime contains Cefazolin see full prescribing information from innovator Adco-Cefotaxime Monograph, Adco-Cefotaxime MSDS, Adco-Cefotaxime FDA label

*** Taking medicines without doctor's advice can cause long-term problems.
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