Adenosine + Cytochrome-C + Sodium Succinate + Nicotinamide
Adenosine + Cytochrome-C + Sodium Succinate + Nicotinamide Uses, Dosage, Side Effects, Food Interaction and all others data.
Each ml sterile eye drops contains- Adenosine BP 2 mg Cytochrome-C Ph. Gr. 0.5 mg Sodium Succinate Ph. Gr. 0.6 mg Nicotinamide BP 10 mg. Preservative: Thiomersal 0.005%Table Of contents
Trade Name | Adenosine + Cytochrome-C + Sodium Succinate + Nicotinamide |
Generic | Adenosine + Cytochrome-C + Sodium Succinate + Nicotinamide |
Type | |
Therapeutic Class | Drugs for lens opacification |
Manufacturer | |
Available Country | Bangladesh |
Last Updated: | September 24, 2024 at 5:38 am |
Uses
This eye drops is used for the treatment of lens opacification.Adenosine + Cytochrome-C + Sodium Succinate + Nicotinamide is also used to associated treatment for these conditions: Paroxysmal Supraventricular Tachycardia, SVT, Tachycardia, Supraventricular, Symptomatic pulmonary arterial hypertension (PAH)Gastrointestinal insufficiency, Hepatic Insufficiency, Macrocytic anemia, Secondary anemia, Vitamin Deficiency, Severe debilitation, Dietary and Nutritional Therapies, Nutritional supplementation, Dietary supplementation
How Adenosine + Cytochrome-C + Sodium Succinate + Nicotinamide works
Agonism of adenosine receptors A1 and A2 reduces conduction time in the atrioventricular node of the heart. Conduction time is decreased by inducing potassium efflux and inhibiting calcium influx through channels in nerve cells, leading to hyperpolarization and and increased threshold for calcium dependent action potentials. Decreased conduction time leads to an antiarrhythmic effect. Inhibition of calcium influx, reduces the activity of adenylate cyclase, relaxing vascular smooth muscle. Relaxed vascular smooth muscle leads to increased blood flow through normal coronary arteries but not stenotic arteries, allowing thallium-201 to be more readily uptaken in normal coronary arteries.
Dosage
Adenosine + Cytochrome-C + Sodium Succinate + Nicotinamide dosage
One drop into the affected eye twice daily.Side Effects
Like any active ingredient, this drug may cause more or less discomfort in some patients. If you feel any discomfort, inform your doctor.Toxicity
Patients experiencing an overdose of adenosine may present with asystole, heart block, or cardiac ischemia; though the effects are generally short lived. Patients experiencing an overdose should be treated with symptomatic and supportive care, which may include a slow intravenous injection of theophylline.
The LD50 in mice is >20 g/kg subcutaneously, 500mg/kg intraperitoneally, and 39.6 µg/kg subcutaneously.[L32048]
Precaution
Do not inject or swallow. In case of concomitant treatment with another ophthalmic solution, wait 15 minutes between each instillation.Interaction
In order to avoid any interaction between different medical products, inform your doctor of any other ongoing treatment in particular with other eye drops.Volume of Distribution
Data regarding the volume of distribution of adenosine are not readily available.
Elimination Route
Data regarding the absorption of adenosine are not readily available.
Half Life
The half life of adenosine in blood is less than 10 seconds.
Clearance
Data regarding the clearance of adenosine are not readily available.
Elimination Route
Adenosine is predominantly eliminated in the urine as uric acid.
Pregnancy & Breastfeeding use
As a general rule, it is recommended to ask your doctor for advice before using this medicine if you are pregnant or nursing mother.Contraindication
This eye drops is contraindicated in patients with known hypersensitivity to any ingredient of the product.Acute Overdose
Accidental ingestion of the medicine is unlikely to cause any toxicity due to low content of ingredients.Storage Condition
Store in below 25⁰C temperature and away from light. Keep out of reach of children. Do not touch the dropper tip to surfaces since this may contaminate the solution. After one month of the opening do not use the medicine of dropper.Innovators Monograph
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