Афлодерм

Афлодерм Uses, Dosage, Side Effects, Food Interaction and all others data.

Афлодерм is synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent.

Афлодерм is a synthetic corticosteroid for topical dermatologic use. The corticosteroids constitute a class of primarily synthetic steroids used topically as anti-inflammatory and antipruritic agents. Афлодерм is a selective glucocorticoid receptor agonist.

Афлодерм
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Афлодерм
Availability	Prescription only
Generic	Alclometasone
Alclometasone Other Names	Alclometasone
Related Drugs	Humira, Cosentyx, Dupixent, prednisone, methotrexate, Remicade, Stelara, cyclosporine, infliximab, Temovate
Type
Formula	C₂₂H₂₉ClO₅
Weight	Average: 408.916 Monoisotopic: 408.170351745
Groups	Approved
Therapeutic Class
Manufacturer
Available Country	Russia
Last Updated:	September 19, 2023 at 7:00 am

Uses

Афлодерм is a topical corticosteroid used to relieve the symptoms of corticosteroid-responsive dermatoses.

For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.

Афлодерм is also used to associated treatment for these conditions: Dermatosis

How Афлодерм works

The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A₂ inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A₂. Афлодерм initially binds the corticosteroid receptor. This complex migrates to the nucleus where it binds to different glucocorticoid response elements on the DNA. This in turn enhances and represses various genes, especially those involved in inflammatory pathways.

Toxicity

Symptoms of overdose include suppression of adrenal glands, temporary decrease in white blood cell counts, symptoms of hypersensitivity (such as skin rash, hives, itching, and difficulty breathing), and increased susceptibility to infection.

Food Interaction

No interactions found.

Афлодерм Disease Interaction

Moderate: diabetes, diaper rash, hyperadrenocorticism, infections, ocular toxicities

Elimination Route

Topical corticosteroids can be absorbed from normal intact skin. Studies have shown that approximately 3% of steroid is absorbed during 8 hours of contact with intact skin of normal volunteers.