AK-Taine

AK-Taine Uses, Dosage, Side Effects, Food Interaction and all others data.

The main site of anesthetic action is the nerve cell membrane where proparacaine interferes with the large transient increase in the membrane permeability to sodium ions that is normally produced by a slight depolarization of the membrane. As the anesthetic action progressively develops in a nerve, the threshold for electrical stimulation gradually increases and the safety factor for conduction decreases; when this action is sufficiently well developed, block of conduction is produced. Several studies indicate that local anesthetics may limit sodium ion permeability by closing the pores through which the ions migrate in the lipid layer of the nerve cell membrane.

AK-Taine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses thereby effecting local anesthetic action. More specifically, proparacaine appears to bind or antagonize the function of voltage gated sodium channels.

AK-Taine
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	AK-Taine
Availability	Prescription only
Generic	Proparacaine
Proparacaine Other Names	Proximetacaina, Proxymetacaine, Proxymetacainum
Related Drugs	lidocaine ophthalmic, Alcaine, Balanced Salt Solution, BSS, BSS Plus, Omidria
Weight	0.5%,
Type	Ophthalmic solution
Formula	C₁₆H₂₆N₂O₃
Weight	Average: 294.3892 Monoisotopic: 294.194342708
Groups	Approved, Vet approved
Therapeutic Class	Ocular perioperative drugs
Manufacturer
Available Country	United States,
Last Updated:	September 19, 2023 at 7:00 am

Uses

AK-Taine is used for procedures in which a topical ophthalmic anesthetic is used for: corneal anesthesia of short duration, e.g. tonometry, gonioscopy, removal of corneal foreign bodies, and for short corneal and conjunctival procedures. It is also used for use prior to surgical operations such as cataract extraction.

AK-Taine is also used to associated treatment for these conditions: Local anesthesia therapy

How AK-Taine works

The exact mechanism whereby proparacaine and other local anesthetics influence the permeability of the cell membrane is unknown; however, several studies indicate that local anesthetics may limit sodium ion permeability through the lipid layer of the nerve cell membrane. AK-Taine may alter epithelial sodium channels through interaction with channel protein residues. This limitation prevents the fundamental change necessary for the generation of the action potential.

Dosage

AK-Taine dosage

Deep anesthesia as in cataract extraction: Instill 1 drop to the eye every 5 to 10 minutes for 5 to 7 doses.

Removal of sutures: Instill 1 or 2 drops to the eye 2 or 3 minutes before removal of stitches.

Removal of foreign bodies: Instill 1 or 2 drops to the eye prior to operating.

Tonometry: Instill 1 or 2 drops to the eye immediately before measurement.

Side Effects

Occasional temporary stinging, burning and conjunctival redness may occur with the use of AK-Taine.

Precaution

Prolonged use of a topical ocular anesthetic is not recommended. It may produce permanent corneal opacification with accompanying visual loss.

Food Interaction

No interactions found.

Pregnancy & Breastfeeding use

Use in pregnancy: It is not known whether AK-Taine can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. AK-Taine should be administered to a pregnant woman only if clearly needed.

Use in lactation: It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when AK-Taine is administered to a nursing mother.

Contraindication

AK-Taine eye drops should be considered contraindicated in patients with known hypersensitivity to any of the ingredients of AK-Taine Hydrochloride.

Special Warning

Pediatric Use: Safety and effectiveness of AK-Taine ophthalmic solution in pediatric patients have been established. Use of AK-Taine is supported by evidence from adequate and well-controlled studies in adults and children over the age of twelve, and safety information in neonates and other pediatric patients.

Geriatric Use: No overall clinical differences in safety or effectiveness have been observed between the elderly and other adult patients.

Storage Condition

Store bottles under refrigeration at 2° to 8° C & protect from light. It is desirable that the contents should not be used more than 4 weeks after first opening of the bottle. If solution shows more than a faint yellow color, it should not be used. Keep bottle tightly closed.