Alcohol diclorobencílico
Alcohol diclorobencílico Uses, Dosage, Side Effects, Food Interaction and all others data.
Alcohol diclorobencílico is a mild antiseptic with a broad spectrum for bacterial and virus associated with mouth and throat infections. Alcohol diclorobencílico is considered as an active ingredient found in several marketed OTC products by Health Canada which has categorized this agent as an anatomical therapeutic chemical. On the other hand, dichlorobenzyl alcohol is categorized by the FDA in the inactive ingredient for approved drug products.
In vitro studies with the combination of dichlorobenzyl alcohol and amylmetacresol have shown a virucidal against a number of viruses associated with the common cold which is observed by a reduction in the viral load. In clinical trials, administration of dichlorobenzyl alcohol lozenges has been shown to generate a reduced throat soreness and to provide pain relief and relief from difficulty in swallowing 5 minutes after administration. This effect can last for even 2 hours. The relief effect was shown to reach a steady-state after 45 minutes.
| Trade Name | Alcohol diclorobencílico |
| Generic | Dichlorobenzyl alcohol |
| Dichlorobenzyl alcohol Other Names | Alcohol diclorobencílico |
| Type | |
| Formula | C7H6Cl2O |
| Weight | Average: 177.02 Monoisotopic: 175.9795702 |
| Protein binding | This pharmacokinetic property has not been fully studied. |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Alcohol diclorobencílico is a medication used to treat a sore throat.
Alcohol diclorobencílico in combination with Amylmetacresol is available in over-the-counter products used for symptomatic relief of acute sore throat and postoperative sore throat.
Alcohol diclorobencílico is also used to associated treatment for these conditions: Mouth infection, Throat infections, Oral antisepsis
How Alcohol diclorobencílico works
The use of dichlorobenzyl alcohol has been related to its antibacterial, antiviral and local anesthetic properties. The local anesthetic action of dichlorobenzyl alcohol is thought to be due to a reduced sodium channel blockade. The antiseptic mechanism of action of dichlorobenzyl alcohol is not fully understood but it is thought to be related to a denaturation of external proteins and rearrangement of the tertiary structure proteins.
Toxicity
Fertility and mutagenicity studies do not indicate any effect driven by dichlorobenzyl alcohol. Overdose studies indicate that in systemic overdose there might be a presence of a CNS transitory stimulation followed by CNS and cardiovascular. Chronic administration is not recommended as it might alter the normal microbial balance of the throat. depression In rats, the reported LD50 is of about 2.7 g/kg when administered orally.
Food Interaction
No interactions found.Volume of Distribution
This pharmacokinetic property has not been fully studied.
Elimination Route
Alcohol diclorobencílico is released almost immediately from its formulation and reaches peak concentration after 3-4 minutes. The concentration in saliva after 120 minutes represents about 50% of the administered dose.
Half Life
This pharmacokinetic property has not been fully studied.
Clearance
This pharmacokinetic property has not been fully studied.
Elimination Route
In preclinical trials, dermal administration of dichlorobenzyl alcohol results in renal elimination of 90% of the administered dose. After metabolism, dichlorobenzyl alcohol is excreted in the urine.
Innovators Monograph
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