Aldesulphone
Aldesulphone Uses, Dosage, Side Effects, Food Interaction and all others data.
Aldesulphone is a water-soluble sulfone used as an antileprosy drug. It has been used with limited success in the treatment of dermatitis herpetiformis.
Aldesulphone is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
| Trade Name | Aldesulphone |
| Generic | Sulfoxone |
| Sulfoxone Other Names | Aldesulfone, Aldesulphone |
| Type | |
| Formula | C14H16N2O6S3 |
| Weight | Average: 404.482 Monoisotopic: 404.017048324 |
| Protein binding | 69% |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
For the treatment of leprosy and dermatitis herpetiformis
How Aldesulphone works
Aldesulphone is a competitive inhibitor of bacterial enzyme dihydropteroate synthetase. The normal substrate for the enzyme, para-aminobenzoic acid (PABA) cannot bind as usual. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
Toxicity
Oral, rat LD50: 7000 mg/kg
Elimination Route
Rapidly absorbed.
Half Life
3-8 hours
Innovators Monograph
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