Aldex AN
Aldex AN Uses, Dosage, Side Effects, Food Interaction and all others data.
Aldex AN is a first-generation antihistamine. It can be used by itself as a short-term sedative and in combination with other drugs to provide night-time allergy and cold relief. Aldex AN is also used in combination with the analgesics paracetamol (acetaminophen) and codeine as an analgesic/calmative preparation, and is prescribed in combination with vitamin B6 (pyridoxine) to prevent morning sickness in pregnant women.
Aldex AN is an antihistamine derived from monoethanolamine possessing antimuscarinic and pronounced sedative effects.
Aldex AN is an antihistamine commonly used as a sleep aid. This drug is also used to relieve symptoms of hay fever (allergic rhinitis), hives (rash or itching), and other allergic reactions. Aldex AN is a member of the ethanolamine class of antihistamines and has anti-allergy power far superior to virtually every other antihistamine on the market, with the exception of diphenhydramine (Benadryl). It is also the most powerful over-the-counter sedative available in the United States, and more sedating than many prescription hypnotics. In a study, it was found to be superior to even the barbiturate, phenobarbital for use as a sedative. Aldex AN is also a potent anticholinergic.
Trade Name | Aldex AN |
Availability | Rx and/or OTC |
Generic | Doxylamine |
Doxylamine Other Names | Dossilamina, Doxilamina, Doxilminio, Doxylamine, Doxylaminum |
Related Drugs | amoxicillin, prednisone, doxycycline, hydroxyzine, amitriptyline, lorazepam, cetirizine, cetirizine ophthalmic, cephalexin, loratadine |
Weight | 25mg |
Type | Oral tablet |
Formula | C17H22N2O |
Weight | Average: 270.3694 Monoisotopic: 270.173213336 |
Groups | Approved, Vet approved |
Therapeutic Class | Anti-emetic drugs, Sedating Anti-histamine |
Manufacturer | |
Available Country | United States |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Aldex AN is used for Hypersensitivity reactions, Insomnia
Aldex AN is also used to associated treatment for these conditions: Common Cold, Flu Symptoms, Insomnia, Mild Allergic Rhinitis, Nausea, Vomiting
How Aldex AN works
Like other antihistamines, doxylamine acts by competitively inhibiting histamine at H1 receptors. It also has substantial sedative and anticholinergic effects.
Dosage
Aldex AN dosage
Hypersensitivity reactionn: 25 mg every 4-6 hr. Max: 150 mg daily.
Insomnia: 25 mg given 30 minutes before retiring at night.
Should be taken with food. Take with food or milk.
Side Effects
Acute dystonic reactions and long-lasting impaired consciousness in child. CNS depression including slight drowsiness to deep sleep, lassitude, dizziness, incoordination. Headache, psychomotor impairment and antimuscarinic effects. Rarely rashes and hypersensitivity reactions, blood disorders, convulsions, sweating, myalgia, extrapyramidal effects, tremor, confusion, tinnitus, hypotension, hair loss.
Toxicity
Signs of overdose include wheezing, tightness in the chest, fever, itching, bad cough, blue skin color, fits, swelling of face, lips, tongue, or throat.
Precaution
May impair ability to drive and operate machinery. Angle-closure galucoma, urinary retention, prostatic hypertrophy or pyloroduodenal obstruction; epilepsy; hepatic impairment. Elderly. Lactation.
Interaction
Enhance effects of CNS depressants eg alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytic sedatives and antipsychotics. Atropine, TCAs, MAOIs. Can mask signs of ototoxicity caused by aminoglycosides.
Food Interaction
- Avoid alcohol. Co-administration may increase drowsiness and fall risk.
[Moderate] GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents.
Use in combination may result in additive central nervous system depression and
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol.
Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
Aldex AN Drug Interaction
Moderate: diphenhydramine, diphenhydramine, duloxetine, duloxetine, alprazolam, alprazolam, cetirizine, cetirizineUnknown: omega-3 polyunsaturated fatty acids, omega-3 polyunsaturated fatty acids, acetaminophen, acetaminophen, acetaminophen, acetaminophen, cyanocobalamin, cyanocobalamin, ascorbic acid, ascorbic acid, cholecalciferol, cholecalciferol
Aldex AN Disease Interaction
Major: depressionModerate: anticholinergic effects, asthma/COPD, cardiovascular, renal/liver disease, glaucoma, liver disease, resp depression
Elimination Route
Readily absorbed via the gastrointestinal tract.
Half Life
10 hours
Pregnancy & Breastfeeding use
Category A: Controlled studies in women fail to demonstrate a risk to the fetus in the 1st trimester (and there is no evidence of a risk in later trimesters), and the possibility of fetal harm remains remote.
Contraindication
Severe liver disease; avoid alcohol; premature infants or full-term neonates.
Storage Condition
Store at 15-30°C.
Innovators Monograph
You find simplified version here Aldex AN
Aldex AN contains Doxylamine see full prescribing information from innovator Aldex AN Monograph, Aldex AN MSDS, Aldex AN FDA label