Aldonil Plus

Aldonil Plus Uses, Dosage, Side Effects, Food Interaction and all others data.

Epalrestat is aldose reductase inhibitor. The aldose reductase inhibitors have a distinct mechanism of action, affecting the underlying disease process in diabetic neuropathy, although the extent of the polyol pathway involvement is yet to be determined. Epalrestat reduces sorbitol accumulation in the sciatic nerve, erythrocytes. Epalrestat may improve motor and sensory nerve conduction velocity and subjective neuropathy symptoms.

Mecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.

Aldonil Plus
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Aldonil Plus
Generic	Epalrestat + Mecobalamin
Weight	150mg
Type	Tablet
Therapeutic Class
Manufacturer	Zydus Cadila Healthcare Ltd
Available Country	India
Last Updated:	September 19, 2023 at 7:00 am

Uses

Diabetic neuropathy

Mecobalamin is used for-

Peripheral Neuropathies
Diabetic Neuropathy
Verteberal Syndrome
Nerve Compression Syndrome
Multiple sclerosis
Amyotrophic lateral sclerosis
Parkinson’s disease
Alzheimer’s disease
Diabetic retinopathy
Entrapment neuropathy
Drug induced neuropathy
Megaloblastic anemia due to Vitamin B12 deficiency

Aldonil Plus is also used to associated treatment for these conditions: Vitamin B12 Deficiency, Nutritional supplementation

Dosage

Aldonil Plus dosage

In general, for adults, take 1 tablet (50 mg of the active ingredient) at a time, three times daily, before meal. The dosage may be adjusted according to the age or symptoms.

Tablet: The usual adult dosage is one 500 mcg tablet three times daily. The dosage should be adjusted according to the age of patient and the severity of symptoms.

Injection:

Peripheral neuropathies: The usual adult dosage is one ampoule equivalent to 500 mcg of Mecobalamin, administered intramuscularly or intravenously three times a week.The dosage should be adjusted according to the age of patient and the severity of symptoms.
Megaloblastic anemia: The usual adult dosage is one ampoule equivalent to 500 mcg of Mecobalamin, administered intramuscularly or intravenously three times a week. After about two months of administration, dosage should be changed to one ampoule equivalent to 500 mcg of Mecobalamin every one to three months as maintenance therapy

Side Effects

The most commonly reported adverse reactions include abdominal pain, nausea, rash, itch, erythema and blister.

Generally Mecobalamin is well tolerated. However, a few side effects like GI discomfort (including anorexia, nausea or diarrhea) & rash may be seen after administration of Mecobalamin.

Precaution

Urine may turn yellowish brown or reddish after taking the medicine, because the yellowish brown or reddish color is attributed to components of this medicine.

The medicine should not be used for months if there is no response at all after its use for a certain period of time.

Interaction

There are no known drug interactions and none well documented.

Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicine. Reduced serum concentrations with oral contraceptives. Reduced effects in anaemia with parenteral chloramphenicol.