Alerease

Alerease Uses, Dosage, Side Effects, Food Interaction and all others data.

An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness.

Alerease is an antihistamine that also induces anticholinergic and sedative effects. Antihistamines competitively antagonize various physiological effects of histamine including increased capillary permeability and dilatation, the formation of edema, the "flare" and "itch" response, and gastrointestinal and respiratory smooth muscle constriction. Within the vascular tree, H1- receptor antagonists inhibit both the vasoconstrictor and vasodilator effects of histamine. Depending on the dose, H1- receptor antagonists can produce CNS stimulation or depression. Most antihistamines exhibit central and/or peripheral anticholinergic activity. Antihistamines act by competitively blocking H1- receptor sites. Antihistamines do not pharmacologically antagonize or chemically inactivate histamine, nor do they prevent the release of histamine.

Trade Name Alerease
Availability Rx and/or OTC
Generic Clemastine
Clemastine Other Names Clemastina, Clemastine, Clemastinum
Related Drugs prednisone, cetirizine, loratadine, fluticasone nasal, promethazine, diphenhydramine, triamcinolone, Benadryl, Zyrtec, Xolair
Weight 1mg/ml, 2mg, 1mg
Type Injection, Tablet
Formula C21H26ClNO
Weight Average: 343.89
Monoisotopic: 343.170292166
Groups Approved, Investigational
Therapeutic Class
Manufacturer Siza International (pvt) Ltd,
Available Country Pakistan
Last Updated: September 19, 2023 at 7:00 am
Alerease
Alerease

Uses

Alerease is an antihistamine with sedative and anticholinergic effects used to treat the symptoms of allergic rhinitis.

For the relief of symptoms associated with allergic rhinitis such as sneezing, rhinorrhea, pruritus and acrimation. Also for the management of mild, uncomplicated allergic skin manifestations of urticaria and angioedema. Used as self-medication for temporary relief of symptoms associated with the common cold.

Alerease is also used to associated treatment for these conditions: Allergic Rhinitis (AR), Angioedema, Common Cold, Urticaria

How Alerease works

Alerease is a selective histamine H1 antagonist and binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.

Toxicity

Oral LD50 in rat and mouse is 3550 mg/kg and 730 mg/kg, respectively. Antihistamine overdosage reactions may vary from central nervous system depression to stimulation. In children, stimulation predominates initially in a syndrome which may include excitement, hallucinations, ataxia, incoordination, muscle twitching, athetosis, hyperthermia, cyanosis convulsions, tremors, and hyperreflexia followed by postictal depression and cardio-respiratory arrest. Convulsions in children may be preceded by mild depression. Dry mouth, fixed dilated pupils, flushing of the face, and fever are common. In adults, CNS depression, ranging from drowsiness to coma, is more common.

Food Interaction

  • Avoid alcohol.
  • Take with food.

[Moderate] GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents.

Use in combination may result in additive central nervous system depression and
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol.

Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

Elimination Route

Rapidly absorbed from the gastrointestinal tract.

Elimination Route

Urinary excretion is the major mode of elimination.

Innovators Monograph

You find simplified version here Alerease

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http://classyfire.wishartlab.com/tax_nodes/C0001030
http://classyfire.wishartlab.com/tax_nodes/C0002239
http://classyfire.wishartlab.com/tax_nodes/C0001167
http://classyfire.wishartlab.com/tax_nodes/C0004139
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0001516
http://classyfire.wishartlab.com/tax_nodes/C0004150
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:3738
http://www.hmdb.ca/metabolites/HMDB0014428
http://www.genome.jp/dbget-bin/www_bget?drug:D03535
http://www.genome.jp/dbget-bin/www_bget?cpd:C06913
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=26987
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506492
https://www.chemspider.com/Chemical-Structure.25129.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=94606
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=2578
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=3738
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1626
https://zinc.docking.org/substances/ZINC000000402830
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP000322
http://www.pharmgkb.org/drug/PA164776997
http://www.rxlist.com/cgi/generic3/clemast.htm
https://www.drugs.com/cdi/clemastine.html
https://en.wikipedia.org/wiki/Clemastine
*** Taking medicines without doctor's advice can cause long-term problems.
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