Alfence

Alfence Uses, Dosage, Side Effects, Food Interaction and all others data.

Alfence (previously APD-356), a highly selective 5HT2C receptor agonist, is used for the treatment of obesity. It has been shown to reduce body weight and food intake in animal models of obesity, and it is thought that targeting the 5HT2C receptor may alter body weight by regulating satiety. Alfence is marketed as a salt form called Belviq, which is lorcaserin hydrochloride.

Alfence produced a dose-dependent weight loss over a 12-week period by promoting satiety and decreasing food consumption.

Trade Name Alfence
Availability Discontinued
Generic Lorcaserin
Lorcaserin Other Names Lorcaserin, Lorqess
Related Drugs phentermine, Victoza, semaglutide, Wegovy, Saxenda, liraglutide, Contrave, Qsymia, Alli
Weight 10mg
Type Tablet
Formula C11H14ClN
Weight Average: 195.69
Monoisotopic: 195.0814772
Protein binding

Lorcaserin hydrochloride has a plasma protein binding of approximately 70%.

Groups Approved
Therapeutic Class
Manufacturer Sun Pharma
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Alfence
Alfence

Uses

Alfence is a serotonin 2C receptor agonist used in conjunction with physical activity and calorie restriction for weight loss in obese patients with a body mass index (BMI) of 30 and above, and in overweight patients with weight-related comorbidities.

For the treatment of obesity, as an adjunct to a reduced-calorie diet and increased physical activity.

Alfence is also used to associated treatment for these conditions: BMI >30 kg/m2

How Alfence works

Although the exact mechanism is unknown, it is believed to involve the selective activation of 5-HT2C receptors in the anorexigenic pro-opiomelanocortin neurons in the arcuate nucleus of the hypothalamus. This results in decreased food intake and satiety by promoting the release of alpha-melanocortin stimulating hormone, which acts on melanocortin-4 receptors.

Toxicity

Most common adverse reactions include hypoglycemia (diabetic patients), headache, back pain,fatigue, decrease in lymphocytes,upper respiratory tract infection, and nasopharyngitis. Moreover, the safety and efficacy of coadministration with other weight loss products has not been established, and cardiovascular effects on mortality and morbidity have not been established.

Food Interaction

  • Take with or without food.

[Minor] Food does not appear to significantly affect the absorption and oral bioavailability of lurasidone.

In twelve adult volunteers (6 men and 6 women), administration of a single 10 mg oral dose of lorcaserin following a high-fat (approximately 50% of total caloric content of the meal) and high-calorie (approximately 800 to 1000 calories) meal resulted in less than 10% increases in lorcaserin peak plasma concentration (Cmax) and systemic exposure (AUC) compared to administration in the fasted state.

The time to reach peak concentration (Tmax) was delayed by approximately 1 hour in the fed state.

Alfence may be administered with or without food.

Volume of Distribution

The volume of distribution was not determined, but lorcaserin distributes to the central nervous system and cerebrospinal fluid.

Elimination Route

Alfence has a peak plasma concentration of about 1.5 - 2 hours, but the bioavailability was not determined.

Half Life

The plasma half life is approximately 11 hours.

Clearance

The clearance value was not determined.

Elimination Route

Alfence is eliminated by hepatic metabolism, and the metabolites are eliminated mostly in the urine (92.3%) and some through feces (2.2%).

Innovators Monograph

You find simplified version here Alfence

*** Taking medicines without doctor's advice can cause long-term problems.
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