Allantoxanic Acid

Allantoxanic Acid Uses, Dosage, Side Effects, Food Interaction and all others data.

Allantoxanic Acid is an adjunct to antineoplastic therapy, used to reduce the toxic side effects associated with chemotherapy. Approved by the European Medicines Agency (EMA) in March 2011, Allantoxanic Acid is available in combination with Gimeracil and Tegafur within the commercially available product "Teysuno". The main active ingredient in Teysuno is Tegafur, a pro-drug of Fluorouracil (5-FU), which is a cytotoxic anti-metabolite drug that acts on rapidly dividing cancer cells. By mimicking a class of compounds called "pyrimidines" that are essential components of RNA and DNA, 5-FU is able to insert itself into strands of DNA and RNA, thereby halting the replication process necessary for continued cancer growth.

Allantoxanic Acid's main role within Teysuno is to reduce the activity of 5-FU within normal gastrointestinal mucosa, and therefore reduce's gastrointestinal toxicity . It functions by blocking the enzyme orotate phosphoribosyltransferase (OPRT), which is involved in the production of 5-FU.

Trade Name Allantoxanic Acid
Generic Oteracil
Oteracil Other Names 5-azaorotic acid, Allantoxanic acid, Oteracil, Oxonate, Oxonic Acid
Type
Formula C4H3N3O4
Weight Average: 157.0843
Monoisotopic: 157.012355599
Protein binding

Oteracil, gimeracil, 5-FU, and tegafur are 8.4%, 32.2%, 18.4%, and 52.3% protein bound, respectively .

Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Allantoxanic Acid
Allantoxanic Acid

Uses

Allantoxanic Acid is a chemotherapy agent used in combination with tegafur, cisplatin and gimeracil to treat advanced gastric cancer.

Allantoxanic Acid is used as an adjunct to antineoplastic therapy. When used within the product Teysuno, oteracil is indicated for the treatment of adults with advanced gastric (stomach) cancer when given in combination with cisplatin.

Allantoxanic Acid is also used to associated treatment for these conditions: Advanced Gastric Cancer

How Allantoxanic Acid works

Allantoxanic Acid's main role within Teysuno is to reduce the activity of 5-FU within normal gastrointestinal mucosa, and therefore reduce's gastrointestinal toxicity . It functions by blocking the enzyme orotate phosphoribosyltransferase (OPRT), which is involved in the production of 5-FU.

Food Interaction

  • Take separate from meals. Allantoxanic Acid should be separated from meals by at least one hour before and after eating.

Volume of Distribution

Although no intravenous data are available for Teysuno in humans, the volume of distribution could be roughly estimated from the apparent volume of distribution and urinary excretion data as 16 l/m2, 17 l/m2, and 23 l/m2 for tegafur, gimeracil and oteracil, respectively .

Elimination Route

After administration of a single dose of 50 mg Teysuno (expressed as tegafur content), median Tmax for Teysuno components tegafur, gimeracil, and oteracil was 0.5, 1.0, and 2.0 hours, respectively .

Half Life

Following a single dose of Teysuno, T1/2 values ranged from 6.7 to 11.3 hours for tegafur, from 3.1 to 4.1 hours for gimeracil, and from 1.8 to 9.5 hours for oteracil .

Elimination Route

Following a single dose of Teysuno, approximately 3.8% to 4.2% of administered tegafur, 65% to 72% of administered gimeracil, and 3.5% to 3.9% of administered oteracil were excreted unchanged in the urine .

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*** Taking medicines without doctor's advice can cause long-term problems.
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