Alpha-1-antiproteinase

Alpha-1-antiproteinase Uses, Dosage, Side Effects, Food Interaction and all others data.

Human alpha-1 proteinase inhibitor or alpha-1-antitrypsin, prepared from human plasma via Cohn alcohol fractionation followed by PEG and zinc chloride fractionation.

Prevents excessive accumulation of active neutrophil elastase and consequent proteolysis of elastin tissues in alveolar lung structures. This prevents the development of emphysema.

Table Of contents

• Alpha-1-antiproteinase
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Alpha-1-antiproteinase
Generic	Alpha-1-proteinase inhibitor
Alpha-1-proteinase inhibitor Other Names	Alfa 1-proteinase inhibitor (human), Alfa-1-antitripsina, Alfa1 antitrypsin, Alpha 1-antitrypsin, Alpha 1-Proteinase Inhibitor, Alpha 1-proteinase inhibitor (human), Alpha 1-proteinase inhibitor, human, Alpha-1 protease inhibitor, Alpha-1 proteinase inhibitor (human), Alpha-1-antiproteinase, Alpha-1-antitrypsin, Alpha-1-proteinase Inhibitor (human), Alpha-1-proteinase inhibitor human, Alpha-1-proteinase Inhibitor, Human, Alpha-1-proteinase inhibitor,human, Alpha1-proteinase Inhibitor, Alpha1-proteinase inhibitor (human), alpha1-proteinase inhibitor human
Type
Formula	C2001H3130N514O601S10
Weight	44324.5 Da
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Alpha-1-antiproteinase is a purified form of human alpha-1 proteinase inhibitor used to treat emphysema patients with associated alpha-1 proteinase inhibitor deficiency.

For chronic augmentation and maintenance therapy in individuals with alpha1-proteinase inhibitor (A1-PI) deficiency and clinical evidence of emphysema.

Alpha-1-antiproteinase is also used to associated treatment for these conditions: Emphysema

How Alpha-1-antiproteinase works

Alpha-1 proteinase inhibitor is a serine protease inhibitor (Serpin). Its primary mechanism is inhibiting the action of the serine protease called elastase (also plasmin and thrombin) in the lungs. The reactive center loop (RCL) of alpha-1 proteinase inhibitor extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable.

Food Interaction

No interactions found.

Volume of Distribution

• 5632 ± 2006 mL [ARALAST NP]
• 5618 ± 1618 mL [Aralast]

Clearance

• 940 +/- 275 mL/day [Patients with congenital α1-PI deficiency with single IV infusion of 60 mg/kg]

Innovators Monograph

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