Altretamina
Altretamina Uses, Dosage, Side Effects, Food Interaction and all others data.
An alkylating agent proposed as an antineoplastic. It also acts as a chemosterilant for male houseflies and other insects.
Altretamina is a novel antineoplastic agent. The precise mechanism by which altretamine exerts its cytotoxic effect is unknown, although a number of theoretical possibilities have been studied. Structurally, altretamine resembles the alkylating agent triethylenemelamine, yet in vitro tests for alkylating activity of altretamine and its metabolitics have been negative. Altretamina has been demonstrated to be efficacious for certain ovarian tumors resistant to classical alkylating agents. Metabolism of altretamine is a requirement of cytotoxicity. Synthetic monohydroxymethylmelamines, and products of altretamine metabolism, in vitro and in vivo, can form covalent adducts with tissue macromolecules including DNA, but the relevance of these reactions to antitumor activity is unknown.
| Trade Name | Altretamina |
| Availability | Discontinued |
| Generic | Altretamine |
| Altretamine Other Names | Altretamin, Altretamina, Altrétamine, Altretamine, Altretaminum, Hexamethylmelamine |
| Related Drugs | carboplatin, doxorubicin, cisplatin, paclitaxel, Avastin, Lynparza |
| Type | |
| Formula | C9H18N6 |
| Weight | Average: 210.2794 Monoisotopic: 210.159294606 |
| Protein binding | 94% |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Altretamina is an antineoplastic agent used in palliative treatment of persistent or recurrent ovarian cancer.
For use as a single agent in the palliative treatment of patients with persistent or recurrent ovarian cancer following first-line therapy with a cisplatin and/or alkylating agent-based combination.
Altretamina is also used to associated treatment for these conditions: Ovarian Cancer, Ovarian Cancer Stage III
How Altretamina works
The precise mechanism by which altretamine exerts its cytotoxic effect is unknown although it is classified as an alkylating anti-neoplastic agent. Through this mechanism, the drug is metabolized into alkylating agents by N-demethylation. These alkylating species consequently damage tumor cells.
Food Interaction
- Take after a meal. Take altretamine after meals and at bedtime.
Altretamina Drug Interaction
Unknown: acetaminophen, acetaminophen, aspirin, aspirin, alprazolam, alprazolam, pseudoephedrine / triprolidine, pseudoephedrine / triprolidine, carboplatin, carboplatin, clotrimazole, clotrimazole
Altretamina Disease Interaction
Major: myelosuppression, neurologic dysfunctionModerate: hepatic impairment
Half Life
4.7-10.2 hours
Elimination Route
Human urinary metabolites were Ndemethylated homologues of altretamine with <1% unmetabolized altretamine excreted at 24 hours.
Innovators Monograph
You find simplified version here Altretamina
