Aluminium Chlorohydrate

Aluminium Chlorohydrate Uses, Dosage, Side Effects, Food Interaction and all others data.

Aluminium Chlorohydrate is a group of water-soluble aluminum complexes with the general formula AlnCl(3n-m)(OH)m. It is included up to 25% in over-the-counter hygiene products as an active antiperspirant agent. The primary site of action of aluminum chlorohydrate is at the level of the stratum corneum layer, which is relatively near the skin surface . It is also used as a coagulant in the water purification process.

Aluminium Chlorohydrate serves to reduce excessive sweating by directly blocking the sweat ducts .

Trade Name Aluminium Chlorohydrate
Generic Aluminum chlorohydrate
Aluminum chlorohydrate Other Names Alchlordrate, Aluminium chlorohydrate, Aluminum chlorhydrate, Aluminum chlorohydrate, Aluminum hydroxychloride
Type
Formula Al2ClH7O6
Weight Average: 192.46
Monoisotopic: 191.9561926
Protein binding

No pharmacokinetic information available.

Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Aluminium Chlorohydrate
Aluminium Chlorohydrate

Uses

Aluminium Chlorohydrate is a compound used as an antiperspirant.

Indicated for use as an antiperspirant.

Aluminium Chlorohydrate is also used to associated treatment for these conditions: Bullae of the feet, Excessive sweating and body odor, Hyperhidrosis, Sweating, Secondary skin infection

How Aluminium Chlorohydrate works

Aluminum salts plug eccrine sweat pores and forms aggregates with swear proteins that bind to the wall of the sweat duct and form a tenuous membrane .

Toxicity

Dermal and oral LD50 in rat is > 2000 mg/kg .

Food Interaction

No interactions found.

Volume of Distribution

No pharmacokinetic information available.

Elimination Route

Penetration of aluminum chlorohydrate following dermal application is minimal, with the rate being around 0.01% and up to 0.06% in pre-damaged skin . In a preliminary study, dermally applied aluminium chlorohydrate displayed 0.012% of the applied aluminium being absorbed through the skin, which accounts for 4 mcg of aluminum following a single dermal application . This is about 2.5% of the aluminium typically absorbed by the gut from food over the same time period .

Half Life

No pharmacokinetic information available.

Clearance

No pharmacokinetic information available.

Elimination Route

No pharmacokinetic information available.

Innovators Monograph

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