Aluminium Chlorohydrate

Aluminium Chlorohydrate Uses, Dosage, Side Effects, Food Interaction and all others data.

Aluminium Chlorohydrate is a group of water-soluble aluminum complexes with the general formula AlnCl(3n-m)(OH)m. It is included up to 25% in over-the-counter hygiene products as an active antiperspirant agent. The primary site of action of aluminum chlorohydrate is at the level of the stratum corneum layer, which is relatively near the skin surface . It is also used as a coagulant in the water purification process.

Aluminium Chlorohydrate serves to reduce excessive sweating by directly blocking the sweat ducts .

Aluminium Chlorohydrate
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Aluminium Chlorohydrate
Generic	Aluminum chlorohydrate
Aluminum chlorohydrate Other Names	Alchlordrate, Aluminium chlorohydrate, Aluminum chlorhydrate, Aluminum chlorohydrate, Aluminum hydroxychloride
Type
Formula	Al₂ClH₇O₆
Weight	Average: 192.46 Monoisotopic: 191.9561926
Protein binding	No pharmacokinetic information available.
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Aluminium Chlorohydrate is a compound used as an antiperspirant.

Indicated for use as an antiperspirant.

Aluminium Chlorohydrate is also used to associated treatment for these conditions: Bullae of the feet, Excessive sweating and body odor, Hyperhidrosis, Sweating, Secondary skin infection

How Aluminium Chlorohydrate works

Aluminum salts plug eccrine sweat pores and forms aggregates with swear proteins that bind to the wall of the sweat duct and form a tenuous membrane .

Toxicity

Dermal and oral LD50 in rat is > 2000 mg/kg .

Food Interaction

No interactions found.

Volume of Distribution

No pharmacokinetic information available.

Elimination Route

Penetration of aluminum chlorohydrate following dermal application is minimal, with the rate being around 0.01% and up to 0.06% in pre-damaged skin . In a preliminary study, dermally applied aluminium chlorohydrate displayed 0.012% of the applied aluminium being absorbed through the skin, which accounts for 4 mcg of aluminum following a single dermal application . This is about 2.5% of the aluminium typically absorbed by the gut from food over the same time period .