Aluminum Hydroxide And Magnesium Trisilicate
Aluminum Hydroxide And Magnesium Trisilicate Uses, Dosage, Side Effects, Food Interaction and all others data.
Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects.
Gastric-peptic disease occurs as a result of an imbalance between protective factors, such as mucus, bicarbonate, and prostaglandin secretion, and aggressive factors, such as hydrochloric acid, pepsin, and Helicobacter pylori (H. pylori). Antacids work by restoring acid-base balance, attenuating the pepsin activity and increasing bicarbonate and prostaglandin secretion.
Magnesium trisilicate is an inorganic compound that is used as an antacid in the treatment of peptic ulcers.
Magnesium trisilicate works by increasing the pH of gastric juice via a neutralisation reaction. It also precipitates colloidal silica, which can coat gastrointestinal mucosa conferring further protection.
| Trade Name | Aluminum Hydroxide And Magnesium Trisilicate |
| Generic | Aluminum hydroxide + magnesium trisilicate |
| Weight | 80mg + 14.2mg |
| Type | Oral tablet, chewable |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | United States |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Aluminum hydroxide is an antacid used for the symptomatic relief of heartburn, acid indigestion, and sour stomach.
For relief of heartburn and acid indigestion.
Magnesium trisilicate is an antacid used for the symptomatic treatment of peptic ulcers.
For the treatment of peptic ulcers. Relieving indigestion and heartburn.
Aluminum Hydroxide And Magnesium Trisilicate is also used to associated treatment for these conditions: Abdominal Pain, Acid Reflux, Acid Regurgitation, Acid indigestion, Anginal Pain caused by Gas, Bloating, Colic, Duodenal Ulcer, Dyspepsia, Flatulence, Gastric Ulcer, Gastroesophageal Reflux, Heartburn, Hyperphosphataemia, Pain, Inflammatory, Skin Irritation, Upset stomach, Stomach pains caused by Gastric Acid, Gastric Acid SuppressionAcid Reflux, Acid indigestion, Bloating, Colic, Flatulence, Gastric Ulcer, Heartburn, Upset stomach
How Aluminum Hydroxide And Magnesium Trisilicate works
Aluminum hydroxide is a basic inorganic salt that acts by neutralizing hydrochloric acid in gastric secretions. Aluminum hydroxide is slowly solubilized in the stomach and reacts with hydrochloric acid to form aluminum chloride and water. It also inhibits the action of pepsin by increasing the pH and via adsorption. Cytoprotective effects may occur through increases in bicarbonate ion (HCO3-) and prostaglandins.
The gelatinous silicon dioxide, formed by the reaction of magnesium trisilicate with gastric contents is said to protect ulcerated mucosal surfaces and favor healing.
Toxicity
Adequate doses of magnesium trisilicate may cause diarrhea due to the action of soluble magnesium salts in the enteric tract. Approx 5% of the magnesium is absorbed.
Volume of Distribution
The hydrated silicon dioxide formed in the stomach and passes into the intestinal track.
Elimination Route
Approximately 17-30% of the aluminum chloride formed is absorbed.
The hydrated silicon dioxide formed in the stomach and passes into the intestinal track where, silica can be partly absorbed.
Half Life
16-20 hours
Clearance
Maximum magnesium clearance is directly proportional to creatinine clearance.
Elimination Route
Absorbed aluminum chloride is rapidly eliminated by the kidneys in patients with normal renal function.
Excreted in the urine.
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