Amben Ethyl Ester
Amben Ethyl Ester Uses, Dosage, Side Effects, Food Interaction and all others data.
Amben Ethyl Ester, an ester local anaesthetic, blocks the initiation and conduction of nerve impulses by decreasing the neuronal membrane’s permeability to Na ions, which results in inhibition of depolarisation with resultant blockade of conduction.
Amben Ethyl Ester is indicated for use as a topical anesthetic. It has a duration of action of approximately 10 minutes and a wide therapeutic window. Patients should be counselled regarding the risks of methemoglobinemia.
| Trade Name | Amben Ethyl Ester |
| Generic | Benzocaine |
| Benzocaine Other Names | Amben ethyl ester, Benzocaina, Benzocaine, Benzocainum, Ethyl aminobenzoate, Ethyl p-aminobenzoate, Ethyl p-aminophenylcarboxylate, p-(Ethoxycarbonyl)aniline, p-Carbethoxyaniline, p-Ethoxycarboxylic aniline |
| Type | |
| Formula | C9H11NO2 |
| Weight | Average: 165.1891 Monoisotopic: 165.078978601 |
| Protein binding | Benzocaine binds to both serum albumin and alpha-1-acid glycoprotein. |
| Groups | Approved, Investigational |
| Therapeutic Class | Local & Surface anesthesia |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
For the temporary relief of pain due to minor injury or irritation of the mouth and gums like Toothache, Sore gums, Canker sores, Braces, Minor dental procedures, Dentures
Amben Ethyl Ester is also used to associated treatment for these conditions: Acute Sore Throat Pain, Dental Pain, Gangrene Stomatitis, Gingivitis, Hemorrhoids, Laryngitis, Pharyngitis, Premature Ejaculation, Secondary Bacterial Infection caused by Tonsillectomy, Secondary Bacterial Infection caused by Tooth Extractions, Skin Irritation, Sore Throat, Stomatitis, Sunburn, Teething pain, Tonsillitis, Tooth Pain, Vomiting, Pruritic dermatosis, Ulceration of the mouth, Buccopharyngeal anesthesia
How Amben Ethyl Ester works
Amben Ethyl Ester diffuses into nerve cells where it binds to sodium channels, preventing the channels from opening, and blocking the influx of sodium ions. Nerve cells unable to allow sodium into cells cannot depolarize and conduct nerve impulses.
Dosage
Amben Ethyl Ester dosage
Apply to the affected area up to 4 times daily or as directed by a doctor/dentist. Children under 12 years of age should be supervised during the use of this product. Children under 2 years of age should be consulted to a doctor/dentist prior to the use of this product. An easy application might be done by fixing applicator on the tube’s nozzle. After application, supplied cap should be fixed on top of the applicator.
Side Effects
Side effects are less common. The side effects include allergies, swelling in the mouth or throatetc.
Toxicity
Patients experiencing an overdose may present with local anesthetic systemic toxicity syndrome, decreased cardiovascular function, decreased central nervous system function, cardiac arrest, bradycardia, hypotension, cardiac arrhythmias, syncope, and seizures. Patients should be treated with symptomatic and supportive measures which include airway maintenance, controlling seizures, and hemodynamic stabilization.
Precaution
Patient with asthma, bronchitis, emphysema, heart disease; smokers. Children, Pregnancy and lactation.
Interaction
May antagonise the therapeutic effect of sulfonamides. Anticholinesterases may inhibit the metabolism benzocaine.
Food Interaction
No interactions found.Pregnancy & Breastfeeding use
Pregnancy Category C. Either studies in animals have revealed adverse effects on the fetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the fetus.
Contraindication
Epiglottis (oral spray), methaemoglobinaemia.
Acute Overdose
Symptom: Methaemoglobinaemia, manifested by cyanotic (greyish) skin discolouration, unusual breathing or breathlessness.
Management: Symptomatic and supportive treatment. IV methylene blue 1% may be administered.
Storage Condition
Store between 15-30° C.
Innovators Monograph
You find simplified version here Amben Ethyl Ester
Amben Ethyl Ester contains Benzocaine see full prescribing information from innovator Amben Ethyl Ester Monograph, Amben Ethyl Ester MSDS, Amben Ethyl Ester FDA label
FAQ
What is Amben Ethyl Ester used for?
Amben Ethyl Ester topical is used to reduce pain or discomfort caused by minor skin irritations, sore throat, sunburn, vaginal or rectal irritation, ingrown toenails, hemorrhoids, and many other sources of minor pain on a surface of the body. Amben Ethyl Ester is an ester local anesthetic commonly used as a topical pain reliever or in cough drops. It is the active ingredient in many over-the-counter anesthetic ointments such as products for oral ulcers.
How safe is Amben Ethyl Ester?
Amben Ethyl Ester topical used in the mouth may cause a condition in which the oxygen in your body tissues can become dangerously low. This is a potentially fatal condition called methemoglobinemia. Do not use Amben Ethyl Ester topical if you have ever had methemoglobinemia.
How does Amben Ethyl Ester work?
Amben Ethyl Ester works by blocking nerve signals in your body.
What are the common side effects of Amben Ethyl Ester?
Common side effects of Amben Ethyl Ester are include:
- Bluish-colored lips, fingernails, or palms.
- difficulty breathing.
- dizziness or lightheadedness.
- high fever.
- rapid heart rate.
- worsening of pain, redness, swelling, or irritation in or around the mouth.
Is Amben Ethyl Ester safe during pregnancy?
Amben Ethyl Ester topical is only recommended for use during pregnancy when benefit outweighs risk.
Is Amben Ethyl Ester safe during breastfeeding?
Amben Ethyl Ester has not been studied during breastfeeding, but is unlikely to affect her breastfed infant if it is applied away from the breast.
Can I drink alcohol with Amben Ethyl Ester?
Alcohol and Amben Ethyl Ester creates a that has different effects depending on the dose: many people feel stimulated and strengthened at low doses of alcohol and Amben Ethyl Ester and even mixing a small amount of Amben Ethyl Ester and alcohol is not recommended.
How often can I take Amben Ethyl Ester?
Do not use the Amben Ethyl Ester more than four times a day.
How should I use Amben Ethyl Ester topical?
Use exactly as directed on the label, or as prescribed by your doctor. Read all medication guides or instruction sheets. Your body may absorb more of benzocaine topical if you use too much, if you apply it over large skin areas, or if you apply heat, bandages, or plastic wrap to treated skin areas. Skin that is cut or irritated may also absorb more topical medication than healthy skin.
How long does Amben Ethyl Ester take to work?
Amben Ethyl Ester is a water-insoluble ester-type local anesthetic agent that is mainly useful for topical application. The onset of action is rapid (<1 minute), and the effective duration is 5 to 10 minutes.
What happens if I use Amben Ethyl Ester too much?
An overdose of Amben Ethyl Ester topical applied to the skin can cause life-threatening side effects such as uneven heartbeats, seizure (convulsions), coma, slowed breathing, or respiratory failure (breathing stops).
How much Amben Ethyl Ester is toxic?
The threshold toxic dose for Amben Ethyl Ester is 22-40 mg/kg.
Who should not take Amben Ethyl Ester?
Do not use benzocaine topical if you have ever had methemoglobinemia. Do not use Amben Ethyl Ester topical on a child younger than 2 years old.
What happens if I miss a dose?
Since Amben Ethyl Ester topical is used when needed, you may not be on a dosing schedule. Skip any missed dose if it's almost time for your next dose.
What what happen if I overdose?
Seek emergency medical attention. An overdose of benzocaine topical applied to the skin can cause life-threatening side effects such as uneven heartbeats, seizure (convulsions), coma, slowed breathing, or respiratory failure (breathing stops).
Will Amben Ethyl Ester affect my fertility?
Studies have not been done to see if Amben Ethyl Ester could affect male fertility or increase the chance of birth defects. In general, exposures that fathers or sperm donors have are unlikely to increase the risks to a pregnancy.
Can I drive after taking Amben Ethyl Ester ?
Amben Ethyl Ester does not affect your ability to drive.
Can Amben Ethyl Ester affects my liver?
Please consult your doctor if you have any concerns regarding the usage of Amben Ethyl Ester in patients with liver impairment.
Can Amben Ethyl Ester affects my kidney?
Please consult your doctor if you have any concerns regarding the usage of Amben Ethyl Ester in patients with kidney impairment.
Can I take Amben Ethyl Ester for a long time?
Amben Ethyl Ester should not be used for longer durations unless prescribed by a doctor. If your condition does not improve despite using Amben Ethyl Ester for a week, consult your doctor, he/she may prescribe you an alternate medicine.
Is It safe to use Amben Ethyl Ester on large areas of skin?
The topical form of Amben Ethyl Ester should not be used on large areas of skin, deep puncture wounds, raw or blistered skin, and on severe burns or abrasions. Use the smallest amount of Amben Ethyl Ester to numb the skin and to relieve pain.
Is Amben Ethyl Ester safe to treat mouth ulcers ?
Amben Ethyl Ester is used to treat mouth ulcers, canker sores and mouth irritation. Mouth ulcers, also known as canker sores are small, painful lesions which develop in the mouth or at the base of gums.
Can Amben Ethyl Ester be used for teething pain?
Amben Ethyl Ester should not be used to treat teething pain in infants.
can I eat after using Amben Ethyl Ester?
If you are using Amben Ethyl Ester for treating tooth pain, gum pain, or mouth ulcers, avoid eating within 1hour after using Amben Ethyl Ester. Amben Ethyl Ester numbs the skin; this might cause biting of the tongue. Avoid swallowing the topical form of Amben Ethyl Ester while applying it to your gums or inside the mouth.
