Ambroksol Takeda
Ambroksol Takeda Uses, Dosage, Side Effects, Food Interaction and all others data.
Ambroksol Takeda is a metabolite of Bromhexine. It possesses mucokinetic (improvement in mucus transport) and secretolytic (liquefies secretions) properties. Ambroksol Takeda stimulates the serous cells of the glands of the mucous membrane of bronchi, increasing the content of mucus secretion. The mucolytic effect is associated with depolymerization and splitting of mucoproteins and mucopolysaccharide fibres, which leads to reduction in the viscosity of mucus. Expectoration of mucus is facilitated and breathing is eased considerably. Ambroksol Takeda stimulates production of phospholipids of surfactant by alveolar cells. Ambroksol Takeda has anti-inflammatory properties. In patients with COPD, it improves airway patency. Beside these, Ambroksol Takeda also exhibits anti-oxidant activity. Long-term use is possible because of the good tolerability of the preparation.
| Trade Name | Ambroksol Takeda |
| Generic | Ambroxol |
| Ambroxol Other Names | Ambroxol, Ambroxolum, Bisolvon metabolite vIII, Bromhexine metabolite vIII, Bromhexine-metabolite vIII |
| Type | |
| Formula | C13H18Br2N2O |
| Weight | Average: 378.108 Monoisotopic: 375.978589 |
| Protein binding | Approximately 90% |
| Groups | Approved, Investigational |
| Therapeutic Class | Cough expectorants & mucolytics |
| Manufacturer | |
| Available Country | Poland |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
- • Acute and chronic diseases of respiratory tracts associated with viscid mucus including acute and chronic bronchitis
- • Productive cough
- • Inflammatory diseases of Rhinopharyngeal tract (e.g. Laryngitis, Pharyngitis, Sinusitis and Rhinitis) associated with viscid mucus
- • Asthmatic bronchitis, Bronchial asthma with difficult departure of mucus
- • Bronchiectasis
- • Chronic pneumonia.
Ambroksol Takeda is also used to associated treatment for these conditions: Airway secretion clearance therapy
How Ambroksol Takeda works
Ambroksol Takeda is a mucolytic agent. Excessive Nitric oxide (NO) is associated with inflammatory and some other disturbances of airways function. NO enhances the activation of soluble guanylate cyclase and cGMP accumulation. Ambroksol Takeda has been shown to inhibit the NO-dependent activation of soluble guanylate cyclase. It is also possible that the inhibition of NO-dependent activation of soluble guanylate cyclase can suppress the excessive mucus secretion, therefore it lowers the phlegm viscosity and improves the mucociliary transport of bronchial secretions.
Dosage
Ambroksol Takeda dosage
Average daily dose (preferably after meal):Pediatric Drops:
- 0-6 months: 0.5 ml 2 times a day
- 6-12 months: 1 ml 2 times a day
- 1-2 years: 1.25 ml 2 times a day
Syrup:
- 2-5 years: 2.5 ml (1/2 teaspoonful) 2-3 times a day
- 5-10 years: 5 ml (1 teaspoonful) 2-3 times a day
- 10 years and adults: 10 ml (2 teaspoonful) 3 times a day.
Sustained release capsule:
- Adult and children over 12 years old: 1 capsule once daily
Specific application features: Ambroksol Takeda may be prescribed to patients suffering from diabetes mellitus.
Side Effects
Gastrointestinal side-effects like epigastric pain, gastric fullness may occur occasionally. Rarely allergic responses such as eruption, urticaria or angioneurotic edema may occur.
Precaution
Ambroksol Takeda should be given cautiously to patients with gastric and duodenal ulceration or convulsive disorders. Patients with hepatic and renal insufficiency should take it with caution.
Interaction
Ambroksol Takeda has no interaction with cardioactive glycosides, corticosteroids, bronchodilators, diuretics and antibiotics (normally used in the treatment of bronchopulmonary affections). But Ambroksol Takeda should not be taken simultaneously with antitussives (e.g. Codeine) because mucus, which has been liquefied by Ambroksol Takeda, might not be expectorated.
Elimination Route
Rapid and almost complete.
Half Life
7-12 hours
Pregnancy & Breastfeeding use
Pregnancy: Teratogenic and fetal toxicity studies have shown no harmful effect of Ambroksol Takeda. However, it is advised not to use during pregnancy, especially in the 1st trimester.
Lactation: Safety during lactation has not been established.
Contraindication
Contraindicated in known hypersensitivity to Ambroksol Takeda or Bromhexine.
Interaction with other Medicine
Ambroksol Takeda has no interaction with cardioactive glycosides, corticosteroids, bronchodilators, diuretics and antibiotics (normally used in the treatment of bronchopulmonary affections). But Ambroksol Takeda should not be taken simultaneously with antitussives (e.g. Codeine) because mucus, which has been liquefied by Ambroksol Takeda, might not be expectorated.
Innovators Monograph
You find simplified version here Ambroksol Takeda
Ambroksol Takeda contains Ambroxol see full prescribing information from innovator Ambroksol Takeda Monograph, Ambroksol Takeda MSDS, Ambroksol Takeda FDA label
FAQ
What is Ambroksol Takeda used for?
Ambroksol Takeda is used for conditions where there are a lot of thick mucus in the airway passages. Ambroksol Takeda belongs to a group of medications called mucolytics.It is used in the treatment of respiratory diseases associated with viscid or excessive mucus.
How safe is Ambroksol Takeda?
Ambroksol Takeda is a safe and well-tolerated treatment of bronchopulmonary diseases with a well-balanced and favorable benefit-risk profile.
How does Ambroksol Takeda work?
Ambroksol Takeda works by thinning down the mucus in the airway passages, thus making the mucus less sticky and it also facilitates the removal of the mucus from the airways.
What are the common side effects of Ambroksol Takeda?
Common side effects of Ambroksol Takeda are include:
- Nausea
- Vomiting
- Diarrhea
- Gastrointestinal side effects
- Skin rash
- itching
- Infections
- Allergies
- Upset stomach
- Dizziness
- Weakness
- Dry mouth
- Indigestion
- Numbness in throat
- Numbness in mouth
- Taste disturbances
Is Ambroksol Takeda safe during pregnancy?
Ambroksol Takeda is not advisable to taken during the first trimester of pregnancy. Please seek your doctor's or pharmacist's advice before using Ambroksol Takeda if you are pregnant.
Is Ambroksol Takeda safe during breastfeeding?
As Ambroksol Takeda is excreted in breast milk, it is not recommended to be taken while breastfeeding. Please seek your doctor's or pharmacist's advice before using this medication if you breastfeeding.
Can I drink alcohol with Ambroksol Takeda?
No. Even though you can readily find products containing dextromethorphan OTC, these medicines can be very dangerous when mixed with alcohol.
Can I drive after taking Ambroksol Takeda?
It is advisable not to drive any motor vehicle or operate heavy machinery as increased drowsiness and dizziness can occur after taking.
When should be taken of Ambroksol Takeda?
The recommended dose is 30mg to be taken three times a day.
How long does Ambroksol Takeda take to work?
When administered orally onset of action occurs after about 30 minutes.
How long should I take Ambroksol Takeda?
Ambroksol Takeda was administered intramuscularly daily for 6-10 days at the following dosages: 1.7 mg/kg (children <2 years), 1.6 mg/kg (children 2-5 years) and 1.2 mg/kg (6-10 years).
What happens if I miss a dose?
If you miss a dose, use this drug as soon as you find it. Skip the missed dose and restart your dosing schedule if it is close to the time of your next dose. Do not use an additional dose in order to make up for the missing dose.
What happens if I overdose of Ambroksol Takeda?
Do not take more than the dosage given. Your symptoms will not be changed by taking more medication; they can instead cause poisoning or severe side effects. If you believe that you or someone else might have overdosed on Ambroksol Takeda Hydrochloride Syrup, please go to the nearest hospital or nursing home emergency room.
Who should not take Ambroksol Takeda?
If you have serious gastric ulceration, liver or kidney issues, notify your healthcare professionals. If you have a confirmed history of an allergy to Ambroksol Takeda, or any of the other ingredients mentioned in the medicine, this drug should be avoided.
Can I take Ambroksol Takeda on an empty stomach?
The tablets may be taken with or without food.
Is Ambroksol Takeda for dry cough?
Ambroksol Takeda is more effective in productive cough treatment associated with the formation of sticky and thick mucus in the airway passages and is difficult to clear.Ambroksol Takeda reduces its thickness and makes its removal easier from the airways passage.
Is Ambroksol Takeda good for itchy throat?
Ambroksol Takeda has a beneficial pain-relieving effect in patients with acute sore throat, superior to that achieved by sucking a placebo lozenge.
Is Ambroksol Takeda a steroid?
No, it is not an antibiotic or steroid; it belongs to a class of medicines called Expectorants or Mucolytics. It has no known effect against infections.
How often should I take Ambroksol Takeda?
The recommended dose for adults is 1 tablet 3 times daily. For better effect, the patient may administer 2 tablets 2 times daily. The tablets should be taken with liquid.
Is Ambroksol Takeda an antibiotic?
Ambroksol Takeda is a mucolytic agent used in the treatment of respiratory diseases.
