Amisalin

Amisalin Uses, Dosage, Side Effects, Food Interaction and all others data.

A derivative of procaine with less CNS action.

Amisalin is an agent indicated for production of local or regional anesthesia and in the treatment of ventricular tachycardia occurring during cardiac manipulation, such as surgery or catheterization, or which may occur during acute myocardial infarction, digitalis toxicity, or other cardiac diseases. The mode of action of the antiarrhythmic effect of Amisalin appears to be similar to that of procaine and quinidine. Ventricular excitability is depressed and the stimulation threshold of the ventricle is increased during diastole. The sinoatrial node is, however, unaffected.

Amisalin
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Amisalin
Availability	Prescription only
Generic	Procainamide
Procainamide Other Names	Procainamida, Procainamide, Procaïnamide, Procainamidum
Related Drugs	propranolol, amiodarone, lidocaine, verapamil, Inderal, dofetilide
Type
Formula	C₁₃H₂₁N₃O
Weight	Average: 235.3253 Monoisotopic: 235.168462309
Protein binding	15 to 20%
Groups	Approved
Therapeutic Class
Manufacturer
Available Country	Japan
Last Updated:	September 19, 2023 at 7:00 am

Uses

Amisalin is a medication used to treat life threatening ventricular arrhythmias.

For the treatment of life-threatening ventricular arrhythmias.

Amisalin is also used to associated treatment for these conditions: Supraventricular Arrhythmias, Ventricular Tachycardia (VT), Life-threatening ventricular arrhythmias, Pre-excited atrial fibrillation

How Amisalin works

Amisalin is sodium channel blocker. It stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses thereby effecting local anesthetic action.

Toxicity

LD₅₀=95 mg/kg (rat, IV); LD₅₀=312 mg/kg (mouse, oral); LD₅₀=103 mg/kg (mouse, IV); LD₅₀=250 mg/kg (rabbit, IV)

Food Interaction

Avoid alcohol.
Take with food. Food reduces irritation.

Amisalin Alcohol interaction

[Minor] Ethanol may increase the acetylation of procainamide.

Subtherapeutic plasma levels of procainamide may result in some patients.

Because the acetylated metabolite of procainamide also possesses antiarrhythmic properties, the clinical effects are unclear.

Amisalin Drug Interaction

Major: haloperidol, levofloxacinModerate: ipratropium, olanzapineUnknown: aspirin, etomidate, lorazepam, diltiazem, docusate, warfarin, rosuvastatin, glucose, phenytoin, apixaban, clonazepam, furosemide, atorvastatin, enoxaparin, clopidogrel, ketorolac

Amisalin Disease Interaction

Major: cardiovascular dysfunction, proarrhythmic effects, myelosuppression, sinus-AV node dysfunction, systemic lupus erythematosusModerate: electrolyte imbalance, anticholinergic activity, renal dysfunction

Volume of Distribution

2 L/kg

Elimination Route

75 to 95%

Half Life

~2.5-4.5 hours

Elimination Route

Trace amounts may be excreted in the urine as free and conjugated p-aminobenzoic acid, 30 to 60 percent as unchanged PA, and 6 to 52 percent as the NAPA derivative.