Amisalin

Amisalin Uses, Dosage, Side Effects, Food Interaction and all others data.

A derivative of procaine with less CNS action.

Amisalin is an agent indicated for production of local or regional anesthesia and in the treatment of ventricular tachycardia occurring during cardiac manipulation, such as surgery or catheterization, or which may occur during acute myocardial infarction, digitalis toxicity, or other cardiac diseases. The mode of action of the antiarrhythmic effect of Amisalin appears to be similar to that of procaine and quinidine. Ventricular excitability is depressed and the stimulation threshold of the ventricle is increased during diastole. The sinoatrial node is, however, unaffected.

Trade Name Amisalin
Availability Prescription only
Generic Procainamide
Procainamide Other Names Procainamida, Procainamide, Procaïnamide, Procainamidum
Related Drugs propranolol, amiodarone, lidocaine, verapamil, Inderal, dofetilide
Type
Formula C13H21N3O
Weight Average: 235.3253
Monoisotopic: 235.168462309
Protein binding

15 to 20%

Groups Approved
Therapeutic Class
Manufacturer
Available Country Japan
Last Updated: September 19, 2023 at 7:00 am
Amisalin
Amisalin

Uses

Amisalin is a medication used to treat life threatening ventricular arrhythmias.

For the treatment of life-threatening ventricular arrhythmias.

Amisalin is also used to associated treatment for these conditions: Supraventricular Arrhythmias, Ventricular Tachycardia (VT), Life-threatening ventricular arrhythmias, Pre-excited atrial fibrillation

How Amisalin works

Amisalin is sodium channel blocker. It stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses thereby effecting local anesthetic action.

Toxicity

LD50=95 mg/kg (rat, IV); LD50=312 mg/kg (mouse, oral); LD50=103 mg/kg (mouse, IV); LD50=250 mg/kg (rabbit, IV)

Food Interaction

  • Avoid alcohol.
  • Take with food. Food reduces irritation.

Amisalin Alcohol interaction

[Minor] Ethanol may increase the acetylation of procainamide.

Subtherapeutic plasma levels of procainamide may result in some patients.

Because the acetylated metabolite of procainamide also possesses antiarrhythmic properties, the clinical effects are unclear.

Volume of Distribution

  • 2 L/kg

Elimination Route

75 to 95%

Half Life

~2.5-4.5 hours

Elimination Route

Trace amounts may be excreted in the urine as free and conjugated p-aminobenzoic acid, 30 to 60 percent as unchanged PA, and 6 to 52 percent as the NAPA derivative.

Innovators Monograph

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*** Taking medicines without doctor's advice can cause long-term problems.
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