Amiseven
Amiseven Uses, Dosage, Side Effects, Food Interaction and all others data.
Acetic acid is a product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed) Acetic acid otic (for the ear) is an antibiotic that treats infections caused by bacteria or fungus.
Glycine irrigation solution contains glycine which is an amino acid and a non-electrolyte. It is therefore non-conductive and suitable for irrigation purpose. Glycine Irrigation Solution minimizes the risk of intravascular haemolysis which can occur from absorption of plain water. Glycine Irrigation Solution is rapidly degraded in the liver by glycine oxidase.
Helps trigger the release of oxygen to the energy requiring cell-making process; Important in the manufacturing of hormones responsible for a strong immune system.
| Trade Name | Amiseven |
| Generic | L Isoleucine + L Leucine + L Lysine + L Methionine + L Phenylalanine + L Threonine + L Tryptophan + L Valine + L Arginine + L Histidine + Glycine + L Alanine + L Proline + L Serine + L Cysteine + L Malic Acid + Acetic Acid |
| Weight | 0.51g |
| Type | Solution For Infusion |
| Therapeutic Class | |
| Manufacturer | Hospimax Healthcare Pvt Ltd |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Acetic acid is an antimicrobial agent used to treat susceptible infections of the external auditory canal.
Used to treat infections in the ear canal.
This is used for irrigating fluid of choice in:
- Transurethral resection of prostate.
- Endoscopic procedures within the urinary tract.
- Urinary bladder surgery etc.
Amiseven is also used to associated treatment for these conditions: Acute Otitis Externa, External ear infection NOS, Infection, Bladder irrigation therapyCoronary vascular graft occlusion, Deep Vein Thrombosis, Myocardial Infarction, Stroke, Transient Ischemic Attack, Vascular Occlusion, Bladder distension, Bladder irrigation therapy, Irrigation therapy, Recovery, Amino acid supplementation
How Amiseven works
In the CNS, there exist strychnine-sensitive glycine binding sites as well as strychnine-insensitive glycine binding sites. The strychnine-insensitive glycine-binding site is located on the NMDA receptor complex. The strychnine-sensitive glycine receptor complex is comprised of a chloride channel and is a member of the ligand-gated ion channel superfamily. The putative antispastic activity of supplemental glycine could be mediated by glycine's binding to strychnine-sensitive binding sites in the spinal cord. This would result in increased chloride conductance and consequent enhancement of inhibitory neurotransmission. The ability of glycine to potentiate NMDA receptor-mediated neurotransmission raised the possibility of its use in the management of neuroleptic-resistant negative symptoms in schizophrenia.
Animal studies indicate that supplemental glycine protects against endotoxin-induced lethality, hypoxia-reperfusion injury after liver transplantation, and D-galactosamine-mediated liver injury. Neutrophils are thought to participate in these pathologic processes via invasion of tissue and releasing such reactive oxygen species as superoxide. In vitro studies have shown that neutrophils contain a glycine-gated chloride channel that can attenuate increases in intracellular calcium and diminsh neutrophil oxidant production. This research is ealy-stage, but suggests that supplementary glycine may turn out to be useful in processes where neutrophil infiltration contributes to toxicity, such as ARDS.
Dosage
Amiseven dosage
The total volume of solution used for irrigation depends on the judgment of the attending surgeon. Height from the operating table of 60 cm (approx. 2ft) is likely to cause increased intravascular absorption of glycine.
- Check infusion set and infusion solution prior to use
- Pull moderately to tear off the protective cover of the Eurohead
- Hold lightly the Eurohead but not the bag
- Open the flow regulator fully and hold the giving set on the top white area, but not the membrane venting region
- Insert the spike of the administration set to the Eurohead and fit the connector of the administration set firmly to the needle
- Gradually allow the fluid to flow down to the needle tip and close
- Remove the protective cover of the needle
- Locate the veinpuncture site and clean the site with an antiseptic solution, and then insert the needle
- Securely tape the puncture site
- Securely tape the wings and tubing
- Start infusion while adjusting drip speed
Side Effects
Large intravenous doses of glycine are known to cause nausea and salivation. Other consequences of systemic absorption of glycine include electrolyte loss, diuresis, edaema, thirst, dehydration, cardiovascular and pulmonary disorders.
Toxicity
ORL-RAT LD50 7930 mg/kg, SCU-RAT LD50 5200 mg/kg, IVN-RAT LD50 2600 mg/kg, ORL-MUS LD50 4920 mg/kg; Doses of 1 gram daily are very well tolerated. Mild gastrointestinal symptoms are infrequently noted. In one study doses of 90 grams daily were also well tole.
Precaution
Precautions: Patients with cardiovascular disease should be evaluated after transurethral resection of prostate using glycine. Care should be exercised if the liver or kidney is impaired.
Warning: Aseptic technique is essential while using glycine. Unused portion should be discarded. Do not use if the bottle is leaking, solution is cloudy, contains particles or after expiry date.
Interaction
Additives may be incompatible. When introducing additives, use aseptic technique, mix thoroughly and do not store.
Elimination Route
Absorbed from the small intestine via an active transport mechanism.
Contraindication
Glycine Irrigation Solution is not for injection in any route. It is contraindicated in patients with anuria.
Storage Condition
Store at controlled room temperature, protect from light and heat
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