Amrinonum

Amrinonum Uses, Dosage, Side Effects, Food Interaction and all others data.

Amrinonum (or inamrinone) is a type 3 pyridine phosphodiesterase inhibitor. It is used in the treatment of congestive heart failure.

Amrinonum is a positive inotropic cardiotonic with vasodilator properties, phosphodiesterase inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell.

Table Of contents

• Amrinonum
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Amrinonum
Generic	Amrinone
Amrinone Other Names	Amrinona, Amrinone, Amrinonum, Inamrinone
Type
Formula	C10H9N3O
Weight	Average: 187.198 Monoisotopic: 187.074561925
Protein binding	10 to 49%
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Amrinonum is a positive inotropic agent and phosphodiesterase inhibitor used in the management of treatment of congestive heart failure.

Used in the treatment of congestive heart failure.

How Amrinonum works

Amrinonum is a phosphodiesterase inhibitor (PDE3), resulting in increased cAMP and cGMP which leads to an increase in the calcium influx like that caused by beta-agonists resulting in increased inotropic effect.

Volume of Distribution

• 1.2 L/kg [normal volunteers]

Half Life

5 to 8 hours

Elimination Route

The primary route of excretion in man is via the urine as both inamrinone and several metabolites (N-glycolyl, N-acetate, O-glucuronide and N-glucuronide).

Innovators Monograph

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