Amsidine

Amsidine Uses, Dosage, Side Effects, Food Interaction and all others data.

Aminoacridine derivative that is a potent intercalating antineoplastic agent. It is effective in the treatment of acute leukemias and malignant lymphomas, but has poor activity in the treatment of solid tumors. It is frequently used in combination with other antineoplastic agents in chemotherapy protocols. It produces consistent but acceptable myelosuppression and cardiotoxic effects.

Amsidine is an aminoacridine derivative that is a potent intercalating antineoplastic agent. It is effective in the treatment of acute leukemias and malignant lymphomas, but has poor activity in the treatment of solid tumors. It is frequently used in combination with other antineoplastic agents in chemotherapy protocols. It produces consistent but acceptable myelosuppression and cardiotoxic effects.

Trade Name Amsidine
Generic Amsacrine
Amsacrine Other Names Acridinyl anisidide, Amsacrina, Amsacrine, Amsacrinum, m-AMSA, mAMSA
Type
Formula C21H19N3O3S
Weight Average: 393.459
Monoisotopic: 393.114712179
Protein binding

96-98%

Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Amsidine
Amsidine

Uses

Amsidine is a cytotoxic agent used to induce remission in acute adult leukemia that is not adequately responsive to other agents.

For treatment of acute myeloid leukaemia.

Amsidine is also used to associated treatment for these conditions: Leukemia, Acute, Refractory Leukemia

How Amsidine works

Amsidine binds to DNA through intercalation and external binding. It has a base specificity for A-T pairs. Rapidly dividing cells are two to four times more sensitive to amsacrine than are resting cells. Amsidine appears to cleave DNA by inducing double stranded breaks. Amsidine also targets and inhibits topoisomerase II. Cytotoxicity is greatest during the S phase of the cell cycle when topoisomerase levels are at a maximum.

Toxicity

Symptoms of overdose include nausea and vomiting, diarrhea, some cardiotoxicity (rarely).

Food Interaction

No interactions found.

Elimination Route

Poorly absorbed

Half Life

8-9 hours

Innovators Monograph

You find simplified version here Amsidine

*** Taking medicines without doctor's advice can cause long-term problems.
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