Amsidine
Amsidine Uses, Dosage, Side Effects, Food Interaction and all others data.
Aminoacridine derivative that is a potent intercalating antineoplastic agent. It is effective in the treatment of acute leukemias and malignant lymphomas, but has poor activity in the treatment of solid tumors. It is frequently used in combination with other antineoplastic agents in chemotherapy protocols. It produces consistent but acceptable myelosuppression and cardiotoxic effects.
Amsidine is an aminoacridine derivative that is a potent intercalating antineoplastic agent. It is effective in the treatment of acute leukemias and malignant lymphomas, but has poor activity in the treatment of solid tumors. It is frequently used in combination with other antineoplastic agents in chemotherapy protocols. It produces consistent but acceptable myelosuppression and cardiotoxic effects.
Trade Name | Amsidine |
Generic | Amsacrine |
Amsacrine Other Names | Acridinyl anisidide, Amsacrina, Amsacrine, Amsacrinum, m-AMSA, mAMSA |
Type | |
Formula | C21H19N3O3S |
Weight | Average: 393.459 Monoisotopic: 393.114712179 |
Protein binding | 96-98% |
Groups | Approved, Investigational |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Amsidine is a cytotoxic agent used to induce remission in acute adult leukemia that is not adequately responsive to other agents.
For treatment of acute myeloid leukaemia.
Amsidine is also used to associated treatment for these conditions: Leukemia, Acute, Refractory Leukemia
How Amsidine works
Amsidine binds to DNA through intercalation and external binding. It has a base specificity for A-T pairs. Rapidly dividing cells are two to four times more sensitive to amsacrine than are resting cells. Amsidine appears to cleave DNA by inducing double stranded breaks. Amsidine also targets and inhibits topoisomerase II. Cytotoxicity is greatest during the S phase of the cell cycle when topoisomerase levels are at a maximum.
Toxicity
Symptoms of overdose include nausea and vomiting, diarrhea, some cardiotoxicity (rarely).
Food Interaction
No interactions found.Elimination Route
Poorly absorbed
Half Life
8-9 hours
Innovators Monograph
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