Amylmetacresol
Amylmetacresol Uses, Dosage, Side Effects, Food Interaction and all others data.
Amylmetacresol is an antiseptic available in Canada over-the-counter in a number of lozenges for the treatment of sore throat and minor mouth infections , . Amylmetacresol is often combined with dichlorobenzyl alcohol and menthol in the commonly used sore throat lozenges, known as Strepsils .
The acute sore throat (pharyngitis) is one of the most common conditions for which children are seen in the primary care setting. Pharyngitis is normally caused by viruses and proves benign and self-limiting. Clinically proven, over-the-counter throat lozenges offer rapid and effective relief of acute sore throat symptoms, and are increasingly important in the management of this condition .
The mixture of amylmetacresol throat lozenge medications markedly reduces the infectivity of certain infectious viruses in the throat and in cough droplets, thus reducing opportunities for person-to-person transmission . In addition, it relieves symptoms of sore throat/irritation of the throat , .
| Trade Name | Amylmetacresol |
| Generic | Amylmetacresol |
| Amylmetacresol Other Names | amilmetacresol, Amyl metacresol, Amylmetacresol, amylmetacresolum |
| Type | |
| Formula | C12H18O |
| Weight | Average: 178.275 Monoisotopic: 178.1357652 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Amylmetacresol is an antiseptic used to treat infections in the mouth and throat.
Sore throat, minor mouth and throat infections , , .
Amylmetacresol is also used to associated treatment for these conditions: Canker sores oral, Gingivitis, Inflammatory Disease of the Oral Cavity, Inflammatory Disease of the throat, Laryngitis, Orofacial Pain, Pharyngitis, Sore Throat, Stomatitis, Mouth infection, Mouth soreness, Pain in throat, Sore throat and hoarseness, Throat infections, Oral antisepsis
How Amylmetacresol works
The mechanism of virucidal action is not fully elucidated, however it is suggested that denaturation of external protein spikes, a pH-induced rearrangement of the tertiary structure of attachment proteins, or a selective effect on viral lipid membranes/protein–lipid interaction is responsible for this action .
Amylmetacresol is an antibacterial and antiviral agent, and blocks voltage-gated Na channels in a local anesthetic-like manner .
Toxicity
Oral LD50: 1500 mg/kg (rat)
Adverse effects include hypersensitivity reactions, tongue soreness .
Occasionally, hypersensitivity reactions may occur, manifested by digestive problems such as nausea or dyspepsia. This is extremely rare .
In the case of overdose, management should be symptomatic. In cases of severe overdosage, gastric lavage may be warranted to empty the stomach contents. Saline laxatives and activated charcoal may be administered orally .
Food Interaction
No interactions found.Elimination Route
Rapidly absorbed and eliminated .
Innovators Monograph
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