AN-9

AN-9 Uses, Dosage, Side Effects, Food Interaction and all others data.

Pivaloyloxymethyl butyrate (AN-9), an acyloxyalkyl ester prodrug of butyric acid (BA), exhibited low toxicity and significant anticancer activity in vitro and in vivo. It shows greater potency than BA at inducing malignant cell differentiation and tumor growth inhibition and has demonstrated more favorable toxicological, pharmacological, and pharmaceutical properties than BA in preclinical studies.

Trade Name AN-9
Generic AN-9
AN-9 Other Names Pivaloyloxymethyl butyrate, Pivaloyloxymethylbutyrate, Pivanex
Type
Formula C10H18O4
Weight Average: 202.25
Monoisotopic: 202.12050906
Groups Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
AN-9
AN-9

Uses

Investigated for use/treatment in liver cancer, lung cancer, melanoma, and leukemia (lymphoid).

How AN-9 works

Pivaloyloxymethyl butyrate is a histone deacetylase inhibitor analog of butyric acid that causes apoptosis of cancer cells through signaling cellular differentiation. It is rapidly and extensively transported intracellularly because of its high lipophilicity, where it undergoes esterase-mediated hydrolysis to form pivalic acid, formaldehyde, and BA.

Innovators Monograph

You find simplified version here AN-9

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